ArticleEuropean journal of applied physiology2014
A mathematical model for carbon dioxide elimination: an insight for tuning mechanical ventilation.
Article in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Backstepping Control with Radial Basis Function Network for a Nonlinear Cardiopulmonary System.IFAC-PapersOnLine · 2020Article
- Biomedical engineer's guide to the clinical aspects of intensive care mechanical ventilation.Biomedical engineering online · 2018Review
- Automatic protective ventilation using the ARDSNet protocol with the additional monitoring of electrical impedance tomography.Critical care (London, England) · 2014Article
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Authors and funding
4 authors.
Funding
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Abstract
purposeThe aim is to provide better understanding of carbon dioxide (CO2) elimination during ventilation for both the healthy and atelectatic condition, derived in a pressure-controlled mode. Therefore, we present a theoretical analysis of CO2 elimination of healthy and diseased lungs.
methodsBased on a single-compartment model, CO2 elimination is mathematically modeled and its contours were plotted as a function of temporal settings and driving pressure. The model was validated within some level of tolerance on an average of 4.9% using porcine dynamics.
resultsCO2 elimination is affected by various factors, including driving pressure, temporal variables from mechanical ventilator settings, lung mechanics and metabolic rate.
conclusionDuring respiratory care, CO2 elimination is a key parameter for bedside monitoring, especially for patients with pulmonary disease. This parameter provides valuable insight into the status of an atelectatic lung and of cardiopulmonary pathophysiology. Therefore, control of CO2 elimination should be based on the fine tuning of the driving pressure and temporal ventilator settings. However, for critical condition of hypercapnia, airway resistance during inspiration and expiration should be additionally measured to determine the optimal percent inspiratory time (%TI) to maximize CO2 elimination for treating patients with hypercapnia.
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