ReviewArchives of biochemistry and biophysics2014
Kinetic isotope effects as a probe of hydrogen transfers to and from common enzymatic cofactors.
Review in Archives of biochemistry and biophysics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Nuclear-Electronic Orbital General Rate Theory: Predicting Hydrogen Kinetic Isotope Effects in the Deep Tunneling Regime.Journal of chemical theory and computation · 2026Article
- Transitioning enzyme catalysis towards photocatalysis.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics.The FEBS journal · 2023Article
- C-H Bond Cleavage Is Rate-Limiting for Oxidative C-P Bond Cleavage by the Mixed Valence Diiron-Dependent Oxygenase PhnZ.Biochemistry · 2019Article
- Engineered control of enzyme structural dynamics and function.Protein science : a publication of the Protein Society · 2018Review
- Decarboxylation involving a ferryl, propionate, and a tyrosyl group in a radical relay yields hemeThe Journal of biological chemistry · 2018Article
- Article
- Theory of single-molecule controlled rotation experiments, predictions, tests, and comparison with stalling experiments in F1-ATPase.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The quantum mitochondrion and optimal health.Biochemical Society transactions · 2016Article
- Article
- Enzymatic Kinetic Isotope Effects from First-Principles Path Sampling Calculations.Journal of chemical theory and computation · 2016Article
- Examinations of the Chemical Step in Enzyme Catalysis.Methods in enzymology · 2016Article
- The general base in the thymidylate synthase catalyzed proton abstraction.Physical chemistry chemical physics : PCCP · 2015Article
- Theory for rates, equilibrium constants, and Brønsted slopes in F1-ATPase single molecule imaging experiments.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Activation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction.ACS catalysis · 2015Article
- Concerted versus stepwise mechanism in thymidylate synthase.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Enzymes use a number of common cofactors as sources of hydrogen to drive biological processes, but the physics of the hydrogen transfers to and from these cofactors is not fully understood. Researchers study the mechanistically important contributions from quantum tunneling and enzyme dynamics and connect those processes to the catalytic power of enzymes that use these cofactors. Here we describe some progress that has been made in studying these reactions, particularly through the use of kinetic isotope effects (KIEs). We first discuss the general theoretical framework necessary to interpret experimental KIEs, and then describe practical uses for KIEs in the context of two case studies. The first example is alcohol dehydrogenase, which uses a nicotinamide cofactor to catalyze a hydride transfer, and the second example is thymidylate synthase, which uses a folate cofactor to catalyze both a hydride and a proton transfer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.