ArticleAppetite2014
Incubation of saccharin craving and within-session changes in responding for a cue previously associated with saccharin.
Article in Appetite, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Biomolecular correlates of incubated sucrose-seeking within ventromedial prefrontal cortex are sex- and subregion-selective.Pharmacology, biochemistry, and behavior · 2025Article
- Connecting self-report and instrumental behavior during incubation of food craving in humans.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Linking drug and food addiction: an overview of the shared neural circuits and behavioral phenotype.Frontiers in behavioral neuroscience · 2023Review
- Factors modulating the incubation of drug and non-drug craving and their clinical implications.Neuroscience and biobehavioral reviews · 2021Review
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Effects of Saccharin Consumption on Operant Responding for Sugar Reward and Incubation of Sugar Craving in Rats.Foods (Basel, Switzerland) · 2020Article
- Incubation of food craving in rats: A review.Journal of the experimental analysis of behavior · 2020Review
- Incubation of feeding behavior is regulated by neuromedin U receptor 2 in the paraventricular nucleus of the hypothalamus.Behavioural brain research · 2019Article
- Dopamine in the oval bed nucleus of the stria terminalis contributes to compulsive responding for sucrose in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine.Genes, brain, and behavior · 2018Review
- Sugar Addiction: From Evolution to Revolution.Frontiers in psychiatry · 2018Review
- Structural and Functional Plasticity within the Nucleus Accumbens and Prefrontal Cortex Associated with Time-Dependent Increases in Food Cue-Seeking Behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Perseveration of craving: effects of stimuli conditioned to drugs of abuse versus conventional reinforcers differing in demand.Addiction biology · 2017Article
- Incubation of Cue-Induced Craving in Adults Addicted to Cocaine Measured by Electroencephalography.JAMA psychiatry · 2016Article
- Recent studies of the effects of sugars on brain systems involved in energy balance and reward: Relevance to low calorie sweeteners.Physiology & behavior · 2016Review
- Systemic injection of the DAD1 antagonist SCH 23390 reduces saccharin seeking in rats.Appetite · 2016Article
- Incubation of food craving is independent of macronutrient composition.Scientific reports · 2016Article
- Extended exposure to environmental cues, but not to sucrose, reduces sucrose cue reactivity in rats.Learning & behavior · 2016Article
- Role of cues and contexts on drug-seeking behaviour.British journal of pharmacology · 2014Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Time-dependent increases in cue-induced sucrose seeking after forced abstinence have been described in rats with a history of sucrose self-administration, suggesting sucrose craving "incubates". In the present study, we examined whether the incubation of craving generalizes to the artificial sweetener, saccharin. Thirty-one male Long-Evans rats lever pressed for 0.3% saccharin solution 1h/day for 10 days. On either Day 1 or 30 of forced abstinence, rats responded for 1h for presentation of a tone+light cue previously presented with every saccharin delivery during self-administration training. Rats responded more during this cue-reactivity test session following 30 vs. 1 day of forced abstinence ("incubation of craving"). This result is the first demonstration of the "incubation of saccharin craving" and suggests that a post-ingestive caloric consequence of self-administration is not a necessary condition for the development of incubation of sucrose craving. We also examined the time course (within-session decreases) of active-lever responding during the 1-h cue-reactivity test session. Rats in the Day 30 group responded more than rats in the Day 1 group from the beginning of the test session. In addition, within-session decreases in responding were shallower in slope in the Day 30 than the Day 1 group. These results indicate that "incubation of saccharin craving" enhances the persistence of seeking behavior.
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