ArticleMethods (San Diego, Calif.)2014
Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip.
Article in Methods (San Diego, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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Who cites it
113 citing papers in PubMed, 242 citations in OpenAlex.
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- Maternal allergen-specific IgG might protect the child against allergic sensitization.The Journal of allergy and clinical immunology · 2019Trial
- PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze.Nature communications · 2018Trial
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- Mechanisms, safety and efficacy of a B cell epitope-based vaccine for immunotherapy of grass pollen allergy.EBioMedicine · 2016Trial
- Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children.The Journal of allergy and clinical immunology · 2015Trial
- Reduction in allergen-specific IgE binding as measured by microarray: A possible surrogate marker for effects of specific immunotherapy.The Journal of allergy and clinical immunology · 2015Trial
- Preventive sublingual immunotherapy in preschool children: first evidence for safety and pro-tolerogenic effects.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2014Trial
- Heterologous Expression and Immunoreactivity of Wheat Amylase-Trypsin Inhibitors.International journal of molecular sciences · 2026Article
- Quantum Dot Bioconjugates Enable Order(s)-of-Magnitude Enhancement of Immunoglobulin E Detection Sensitivity.ACS omega · 2026Article
- Concordance between different methods of detecting fungal-specific IgE antibody in asthma.Frontiers in allergy · 2026Article
- Decoding allergy in vitro: Challenges and clinical use of humoral and cellular methods.Allergologie select · 2026Review
- Assessment of Specific IgE Levels to Major Allergens Fel d 1 and Can f 1 Using the AllergochipRF and ImmunoCAP Diagnostic Platforms.Bulletin of experimental biology and medicine · 2025Article
- From skin testing to molecular diagnostics: the precision leap in dust mite allergy diagnosis and clinical translation challenges.Frontiers in allergy · 2025Review
- Multiplex IgE peanut panels: a critical appraisal of assay designs and the good, the bad, and the ugly features of the applied allergen components.Frontiers in allergy · 2025Article
- Article
- Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China.Current allergy and asthma reports · 2024Review
- Allergen Microarrays and New Physical Approaches to More Sensitive and Specific Detection of Allergen-Specific Antibodies.Biosensors · 2024Review
- Single-Domain Antibodies-Novel Tools to Study and Treat Allergies.International journal of molecular sciences · 2024Review
- Gastropod Allergy: A Comprehensive Narrative Review.Current issues in molecular biology · 2024Review
53 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 7 institutions in 7 countries.
Funding
Abstract
Allergy diagnosis based on purified allergen molecules provides detailed information regarding the individual sensitization profile of allergic patients, allows monitoring of the development of allergic disease and of the effect of therapies on the immune response to individual allergen molecules. Allergen microarrays contain a large variety of allergen molecules and thus allow the simultaneous detection of allergic patients' antibody reactivity profiles towards each of the allergen molecules with only minute amounts of serum. In this article we summarize recent progress in the field of allergen microarray technology and introduce the MeDALL allergen-chip which has been developed for the specific and sensitive monitoring of IgE and IgG reactivity profiles towards more than 170 allergen molecules in sera collected in European birth cohorts. MeDALL is a European research program in which allergen microarray technology is used for the monitoring of the development of allergic disease in childhood, to draw a geographic map of the recognition of clinically relevant allergens in different populations and to establish reactivity profiles which are associated with and predict certain disease manifestations. We describe technical advances of the MeDALL allergen-chip regarding specificity, sensitivity and its ability to deliver test results which are close to in vivo reactivity. In addition, the usefulness and numerous advantages of allergen microarrays for allergy research, refined allergy diagnosis, monitoring of disease, of the effects of therapies, for improving the prescription of specific immunotherapy and for prevention are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.