ArticleJournal of the American College of Cardiology2014
Heart failure with preserved ejection fraction: comparison of patients with and without angina pectoris (from the Duke Databank for Cardiovascular Disease).
Article in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).The American journal of cardiology · 2016Trial
- Incorporating angina into the HOpen heart · 2026Article
- Multimodal Data-Driven Explainable Prognostic Model for Major Adverse Cardiovascular Events Prediction in Patients With Unstable Angina and Heart Failure With Preserved Ejection Fraction: Multicenter, Cross-Regional Cohort Study.Journal of medical Internet research · 2025Article
- Coronary microvascular dysfunction and its role in heart failure with preserved ejection fraction for future prevention and treatment.American journal of preventive cardiology · 2025Article
- Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction.Cardiovascular therapeutics · 2023Review
- Pre-hospital delay in patients with acute myocardial infarction in China: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) project.Journal of geriatric cardiology : JGC · 2022Article
- Survival in Patients With Nonischemic Cardiomyopathy With Preserved vs Reduced Ejection Fraction.CJC open · 2021Article
- Early invasive coronary angiography and acute ischaemic heart failure outcomes.European heart journal · 2021Article
- Evaluation and management of heart failure with preserved ejection fraction.Nature reviews. Cardiology · 2020Review
- Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology.Journal of arrhythmia · 2020Article
- Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction Study.Journal of the American Geriatrics Society · 2017Article
- Sodium Glucose Cotransporter-2 Inhibition in Heart Failure: Potential Mechanisms, Clinical Applications, and Summary of Clinical Trials.Circulation · 2017Review
- Prediction of 1-year clinical outcomes using the SYNTAX score in patients with prior heart failure undergoing percutaneous coronary intervention: sub-analysis of the SHINANO registry.Heart and vessels · 2017Observational
- Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2016Review
- Pathophysiology and clinical evaluation of acute heart failure.Nature reviews. Cardiology · 2016Review
- Strategies and methods to study female-specific cardiovascular health and disease: a guide for clinical scientists.Biology of sex differences · 2016Review
- Association between left ventricular end-diastolic pressure and coronary artery disease as well as its extent and severity.International journal of clinical and experimental medicine · 2015Article
- Persistent angina pectoris in ischaemic cardiomyopathy: increased rehospitalization and major adverse cardiac events.European journal of heart failure · 2014Article
- Heart failure with preserved ejection fraction: current understandings and challenges.Current cardiology reports · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThis study investigated the characteristics and outcomes of patients with heart failure with preserved ejection fraction (HFpEF) and angina pectoris (AP).
backgroundAP is a predictor of adverse events in patients with heart failure with reduced EF. The implications of AP in HFpEF are unknown.
methodsWe analyzed HFpEF patients (EF ≥50%) who underwent coronary angiography at Duke University Medical Center from 2000 through 2010 with and without AP in the previous 6 weeks. Time to first event was examined using Kaplan-Meier methods for the primary endpoint of death/myocardial infarction (MI)/revascularization/stroke (i.e., major adverse cardiac events [MACE]) and secondary endpoints of death/MI/revascularization, death/MI/stroke, death/MI, death, and cardiovascular death/cardiovascular hospitalization.
resultsIn the Duke Databank, 3,517 patients met criteria for inclusion and 1,402 (40%) had AP. Those with AP were older with more comorbidities and prior revascularization compared with non-AP patients. AP patients more often received beta-blockers, angiotensin-converting enzyme inhibitors, nitrates, and statins (all p < 0.05). In unadjusted analysis, AP patients had increased MACE and death/MI/revascularization (both p < 0.001), lower rates of death and death/MI (both p < 0.05), and similar rates of death/MI/stroke and cardiovascular death/cardiovascular hospitalization (both p > 0.1). After multivariable adjustment, those with AP remained at increased risk for MACE (hazard ratio [HR]: 1.30, 95% confidence interval [CI]: 1.17 to 1.45) and death/MI/revascularization (HR: 1.29, 95% CI: 1.15 to 1.43), but they were at similar risk for other endpoints (p > 0.06).
conclusionsAP in HFpEF patients with a history of coronary artery disease is common despite medical therapy and is independently associated with increased MACE due to revascularization with similar risk of death, MI, and hospitalization.
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