Evidence map›Paper›PMID 24161223›Full record

ArticleThe Journal of pediatrics2014

Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study.

Iván Sánchez Fernández, Nicholas S Abend, Daniel H Arndt, Jessica L Carpenter, Kevin E Chapman, Karen M Cornett, Dennis J Dlugos, William B Gallentine, Christopher C Giza, Joshua L Goldstein and 9 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02552511 (A Multi-Centre Epidemiology Study on Neonatal Seizure in China), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02552511 recruitingnot on this mapstarted 2015, after this paper: background citation

A Multi-Centre Epidemiology Study on Neonatal Seizure in China

TypeobservationalSponsorChildren's Hospital of Fudan UniversityRan2015 to 2025Enrolled1,400ConditionsSeizures
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Management of Status Epilepticus in Children.Journal of clinical medicine · 2016
    Review
  10. Status Epilepticus.Cold Spring Harbor perspectives in medicine · 2016
    Review
  11. Review
  12. Consensus statement on continuous EEG in critically ill adults and children, part I: indications.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015
    Article
  13. Article
  14. Review
  15. Pediatric status epilepticus management.Current opinion in pediatrics · 2014
    Review
  16. Article
  17. Management of pediatric status epilepticus.Current treatment options in neurology · 2014
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 3 countries.

Iván Sánchez FernándezDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, Spain.
Nicholas S AbendDepartments of Neurology and Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address: abend@email.chop.edu.
Daniel H ArndtDepartment of Pediatrics, Oakland University William Beaumont School of Medicine, Royal Oak, MI; Department of Neurology, Oakland University William Beaumont School of Medicine, Royal Oak, MI.
Jessica L CarpenterDepartment of Neurology, Children's National Medical Center, Washington, DC.
Kevin E ChapmanDivision of Neurology, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO.
Karen M CornettDivision of Pediatric Neurology, Duke University Hospital and Duke University School of Medicine, Durham, NC.
Dennis J DlugosDepartments of Neurology and Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
William B GallentineDivision of Pediatric Neurology, Duke University Hospital and Duke University School of Medicine, Durham, NC.
Christopher C GizaDivision of Neurology, Department of Pediatrics Mattel Children's Hospital and UCLA Brain Injury Research Center, Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Joshua L GoldsteinDivision of Neurology, Children's Memorial Hospital and Northwestern University Feinberg School of Medicine, Chicago, IL.
Cecil D HahnDivision of Neurology, The Hospital for Sick Children and University of Toronto, Toronto, ON.
Jason T LernerDivision of Neurology, Department of Pediatrics Mattel Children's Hospital and UCLA Brain Injury Research Center, Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Joyce H MatsumotoDivision of Neurology, Department of Pediatrics Mattel Children's Hospital and UCLA Brain Injury Research Center, Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Kristin McBainDivision of Neurology, The Hospital for Sick Children and University of Toronto, Toronto, ON.
Kendall B NashDepartment of Neurology, University of California San Francisco, San Francisco, CA.
Eric PayneDivision of Neurology, The Hospital for Sick Children and University of Toronto, Toronto, ON.
Sarah M SánchezDepartments of Neurology and Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Korwyn WilliamsDepartment of Pediatrics, University of Arizona College of Medicine and Barrow's Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ.
Tobias LoddenkemperDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Hospital for Sick Children · CAMattel Children's Hospital · USBoston Children's Hospital · USDuke University Hospital · USUniversity of Pennsylvania · USChildren's Hospital of Philadelphia · USChildren's National · USNorthwestern Memorial Hospital · USOakland University · USUniversity of Arizona · USUniversity of California, San Francisco · USUniversity of Colorado Denver · US

Funding

Impact of Initial Therapy and Response on Long Term Outcome in Children with CAEU01NS045911 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI GLAUSER, TRACY A · 2003 to 2013
$31.1M
2 of 7 EPI4K - Phenotyping Clinical Informatics Core U01NS077276 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWENSTEIN, DANIEL H · 2011 to 2015
$3.1M
Multi-Institutional Pediatric Epilepsy Decision SupportR01LM011124 · NLM · CINCINNATI CHILDRENS HOSP MED CTR · PI PESTIAN, JOHN P · 2011 to 2013
$955k
Non-convulsive seizures in critically ill children:physiology and outcomeK23NS076550 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ABEND, NICHOLAS SCOTT · 2011 to 2015
$877k
Encephalographic MRI and Epilepsy Discharge LocalizationR21NS076859 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ORBACH, DARREN BENJAMIN · 2011 to 2012
$519k
NINDS NIH HHS 1R01NS053998NINDS NIH HHS 1R21NS076859-01NINDS NIH HHS 2U01NS045911NINDS NIH HHS K23 NS076550NINDS NIH HHS K23NS076550NINDS NIH HHS U01NS077276NLM NIH HHS 1R01LM011124
6 · The paper itself

Abstract

objectiveTo describe the prevalence, characteristics, and predictors of electrographic seizures after convulsive status epilepticus (CSE). STUDY

designThis was a multicenter retrospective study in which we describe clinical and electroencephalographic (EEG) features of children (1 month to 21 years) with CSE who underwent continuous EEG monitoring.

resultsNinety-eight children (53 males) with CSE (median age of 5 years) underwent subsequent continuous EEG monitoring after CSE. Electrographic seizures (with or without clinical correlate) were identified in 32 subjects (33%). Eleven subjects (34.4%) had electrographic-only seizures, 17 subjects (53.1%) had electroclinical seizures, and 4 subjects (12.5%) had an unknown clinical correlate. Of the 32 subjects with electrographic seizures, 15 subjects (46.9%) had electrographic status epilepticus. Factors associated with the occurrence of electrographic seizures after CSE were a previous diagnosis of epilepsy (P = .029) and the presence of interictal epileptiform discharges (P < .0005). The median (p25-p75) duration of stay in the pediatric intensive care unit was longer for children with electrographic seizures than for children without electrographic seizures (9.5 [3-22.5] vs 2 [2-5] days, Wilcoxon test, Z = 3.916, P = .0001). Four children (4.1%) died before leaving the hospital, and we could not identify a relationship between death and the presence or absence of electrographic seizures.

conclusionsAfter CSE, one-third of children who underwent EEG monitoring experienced electrographic seizures, and among these, one-third experienced entirely electrographic-only seizures. A previous diagnosis of epilepsy and the presence of interictal epileptiform discharges were risk factors for electrographic seizures.

Indexed as

ElectroencephalographyAdolescentChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMaleMonitoring, PhysiologicPrognosisRetrospective StudiesRisk FactorsSeizuresSpainConvulsive status epilepticusCSEEEGElectroencephalogram

Identifiers

PMID24161223
PMCPMC3946834
OpenAlexW2024625335

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.