ArticleBMC developmental biology2013
c-kit expression profile and regulatory factors during spermatogonial stem cell differentiation.
Article in BMC developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Post-translational modification of proteins in the human testis development pathway.Human reproduction update · 2026Review
- Integrating microarray data and single-cell RNA-seq reveals correlation between kit and nmyc in mouse spermatogonia stem cell population.Frontiers in cell and developmental biology · 2025Article
- Genome editing in mouse spermatogonial stem cell lines targeting the Tex15 gene using CRISPR/Cas9.Frontiers in veterinary science · 2025Article
- Identification of Differentially Expressed Genes and microRNAs in the Gray and White Feather Follicles of Shitou Geese.Animals : an open access journal from MDPI · 2024Article
- How does retinoic acid (RA) signaling pathway regulate spermatogenesis?Histology and histopathology · 2022Review
- Review
- Editorial: Reproductive genomics.Frontiers in genetics · 2022Article
- SCF Improves In Vitro Differentiation of SSCs Through Transcriptionally Up-regulating PRTM1, STRA8, c-KIT, PIWIL2, and OCT4 Genes.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Step by Step about Germ Cells Development in Canine.Animals : an open access journal from MDPI · 2021Review
- FGF9 promotes mouse spermatogonial stem cell proliferation mediated by p38 MAPK signalling.Cell proliferation · 2021Article
- The Progresses of Spermatogonial Stem Cells Sorting Using Fluorescence-Activated Cell Sorting.Stem cell reviews and reports · 2020Review
- Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.Nature communications · 2019Article
- Cardiac c-Kit Biology Revealed by Inducible Transgenesis.Circulation research · 2018Article
- BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis.Nature communications · 2017Article
- Efficacy of naringenin against permethrin-induced testicular toxicity in rats.International journal of experimental pathology · 2016Article
- RA induces differentiation of multipotent P19 cells towards male germ cell.In vitro cellular & developmental biology. Animal · 2015Article
- The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice.Cell death & disease · 2014Article
- Plasticity of male germline stem cells and their applications in reproductive and regenerative medicine.Asian journal of andrologyReview
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been proven that c-kit is crucial for proliferation, migration, survival and maturation of spermatogenic cells. A periodic expression of c-kit is observed from primordial germ cells (PGCs) to spermatogenetic stem cells (SSCs), However, the expression profile of c-kit during the entire spermatogenesis process is still unclear. This study aims to reveal and compare c-kit expression profiles in the SSCs before and after the anticipated differentiation, as well as to examine its relationship with retinoic acid (RA) stimulation.
resultsWe have found that there are more than 4 transcripts of c-kit expressed in the cell lines and in the testes. The transcripts can be divided into short and long categories. The long transcripts include the full-length canonical c-kit transcript and the 3' end short transcript. Short transcripts include the 3.4 kb short transcript and several truncated transcripts (1.9-3.2 kb). In addition, the 3.4 kb transcript (starting from intron 9 and covering exons 10 ~ 21) is discovered to be specifically expressed in the spermatogonia. The extracellular domain of Kit is obtained in the spermatogonia stage, but the intracellular domain (50 kDa) is constantly expressed in both SSCs and spermatogonia. The c-kit expression profiles in the testis and the spermatogonial stem cell lines vary after RA stimulation. The wave-like changes of the quantitative expression pattern of c-kit (increase initially and decrease afterwards) during the induction process are similar to that of the in vivo male germ cell development process.
conclusionsThere are dynamic transcription and translation changes of c-kit before and after SSCs' anticipated differentiation and most importantly, RA is a significant upstream regulatory factor for c-kit expression.
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