Evidence map›Paper›PMID 24160906›Full record

GuidelineAmerican journal of respiratory and critical care medicine2013

An official American Thoracic Society research statement: comparative effectiveness research in pulmonary, critical care, and sleep medicine.

Shannon S Carson, Christopher H Goss, Sanjay R Patel, Antonio Anzueto, David H Au, Stuart Elborn, Joe K Gerald, Lynn B Gerald, Jeremy M Kahn, Atul Malhotra and 6 more

Registry-linked trialOpen access · greenAbstract readPractice Guideline
In one paragraph

Guideline in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03797313 (Observational Study of Expected Acute Respiratory Failure), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03797313 completednot on this mapstarted 2019, after this paper: background citation

Observational Study of Expected Acute Respiratory Failure (ARF) Recovery

TypeobservationalSponsorJohns Hopkins UniversityRan2019 to 2021Enrolled180ConditionsAcute Respiratory Failure, Post Intensive Care Syndrome
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Obstructive Sleep Apnea Endophenotypes.Sleep science (Sao Paulo, Brazil) · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Patients' Outcomes After Acute Respiratory Failure: A Qualitative Study With the PROMIS Framework.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Shannon S Carson
Christopher H Goss
Sanjay R Patel
Antonio Anzueto
David H Au
Stuart Elborn
Joe K Gerald
Lynn B Gerald
Jeremy M Kahn
Atul Malhotra
Richard A Mularski
Kristin A Riekert
Gordon D Rubenfeld
Terri E Weaver
Jerry A Krishnan
American Thoracic Society Comparative Effectiveness Research Working Group
American Thoracic Society · US

Funding

Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Mechanisms Underlying the Aging Predisposition to Obstructive Sleep ApneaR01HL090897 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MALHOTRA, ATUL · 2009 to 2012
$1.8M
Assessment of Upper Airway Mechanics Using Newer EMG TechniquesK24HL093218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2009 to 2013
$857k
NHLBI NIH HHS K24 HL093218NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL090897
6 · The paper itself

Abstract

backgroundComparative effectiveness research (CER) is intended to inform decision making in clinical practice, and is central to patient-centered outcomes research (PCOR). PURPOSE: To summarize key aspects of CER definitions and provide examples highlighting the complementary nature of efficacy and CER studies in pulmonary, critical care, and sleep medicine.

methodsAn ad hoc working group of the American Thoracic Society with experience in clinical trials, health services research, quality improvement, and behavioral sciences in pulmonary, critical care, and sleep medicine was convened. The group used an iterative consensus process, including a review by American Thoracic Society committees and assemblies.

resultsThe traditional efficacy paradigm relies on clinical trials with high internal validity to evaluate interventions in narrowly defined populations and in research settings. Efficacy studies address the question, "Can it work in optimal conditions?" The CER paradigm employs a wide range of study designs to understand the effects of interventions in clinical settings. CER studies address the question, "Does it work in practice?" The results of efficacy and CER studies may or may not agree. CER incorporates many attributes of outcomes research and health services research, while placing greater emphasis on meeting the expressed needs of nonresearcher stakeholders (e.g., patients, clinicians, and others).

conclusionsCER complements traditional efficacy research by placing greater emphasis on the effects of interventions in practice, and developing evidence to address the needs of the many stakeholders involved in health care decisions. Stakeholder engagement is an important component of CER.

Indexed as

Comparative Effectiveness ResearchCritical CareHumansOutcome Assessment, Health CarePulmonary MedicineResearch DesignSleep Medicine Specialty

Identifiers

PMID24160906
PMCPMC5447323
OpenAlexW2119095532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.