ArticleJournal of the American Chemical Society2013
A multistage volumetric bar chart chip for visualized quantification of DNA.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Overview of Gas-Generating-Reaction-Based Immunoassays.Biosensors · 2024Review
- Nanomaterial-assisted microfluidics for multiplex assays.Mikrochimica acta · 2022Review
- Remotely tunable microfluidic platform driven by nanomaterial-mediated on-demand photothermal pumping.Lab on a chip · 2020Article
- Slip-driven microfluidic devices for nucleic acid analysis.Biomicrofluidics · 2019Review
- Quantitative assessment of disease markers using the naked eye: point-of-care testing with gas generation-based biosensor immunochromatographic strips.Journal of nanobiotechnology · 2019Article
- Microfluidic device for the analysis of MDR cancerous cell-derived exosomes' response to nanotherapy.Biomedical microdevices · 2019Article
- Multiplexed Instrument-Free Bar-Chart SpinChip Integrated with Nanoparticle-Mediated Magnetic Aptasensors for Visual Quantitative Detection of Multiple Pathogens.Analytical chemistry · 2018Article
- Integrative volumetric bar-chart chip for rapid and quantitative point-of-care detection of myocardial infarction biomarkers.Lab on a chip · 2016Article
- Recent Progress of Microfluidics in Translational Applications.Advanced healthcare materials · 2016Review
- Nanoporous Glass Integrated in Volumetric Bar-Chart Chip for Point-of-Care Diagnostics of Non-Small Cell Lung Cancer.ACS nano · 2016Article
- A microfluidic platform with digital readout and ultra-low detection limit for quantitative point-of-care diagnostics.Lab on a chip · 2015Article
- Competitive volumetric bar-chart chip with real-time internal control for point-of-care diagnostics.Analytical chemistry · 2015Article
- Nanostructured microfluidic digestion system for rapid high-performance proteolysis.Lab on a chip · 2015Article
- Integration of platinum nanoparticles with a volumetric bar-chart chip for biomarker assays.Angewandte Chemie (International ed. in English) · 2014Article
- Point-of-care technologies for molecular diagnostics using a drop of blood.Trends in biotechnology · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Nucleic acid detection is critical in disease diagnosis as well as in the environmental assays of harmful bacteria or viruses and forensic applications. Current methods for visualized quantification of DNA require costly and sophisticated instruments. Here, we report a multistage propelled volumetric bar chart chip (MV-Chip) for multiplexing and quantitative detection of DNA. Because of its "rocket-like" propelling reaction, the predeposited platinum films could perform cascade amplification and detect as low as 20 pM DNA targets after three stages of platinum-catalyzed propulsion. The resulting ink bar charts can be directly read out by the naked eye, and the signal shows little interference from serum. Single-nucleotide polymorphism and multiplex DNA detection were carried out to demonstrate this powerful application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.