ArticleJournal of neuroinflammation2013
Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation.
Article in Journal of neuroinflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Sex and Diet Biased Effect of L-DOPA on Iron Accumulation in the Ventral Midbrain.Journal of neurochemistry · 2026Article
- Combined Manganese-Iron Exposure Reduced Oxidative Stress is Associated with the NRF2/NQO1 Pathway in Astrocytic C8-D1A Cells.Biological trace element research · 2026Article
- Ferroptosis-associated transcriptional factors in neurological diseases: molecular mechanisms and therapeutic prospects.Experimental & molecular medicine · 2025Review
- Altered Ca2+ responses and antioxidant properties in Friedreich's ataxia-like cerebellar astrocytes.Journal of cell science · 2025Article
- Redox and Calcium Alterations of a Müller Cell Line Exposed to Diabetic Retinopathy-Like Environment.Frontiers in cellular neuroscience · 2022Article
- Neuroimaging measures of iron and gliosis explain memory performance in aging.Human brain mapping · 2021Article
- Gα13 Contributes to LPS-Induced Morphological Alterations and Affects Migration of Microglia.Molecular neurobiology · 2021Article
- Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.Acta neuropathologica · 2021Article
- Article
- BM-MSC Transplantation Alleviates Intracerebral Hemorrhage-Induced Brain Injury, Promotes Astrocytes Vimentin Expression, and Enhances Astrocytes Antioxidation via the Cx43/Nrf2/HO-1 Axis.Frontiers in cell and developmental biology · 2020Article
- Upregulation of Peroxiredoxin 3 ProtectsOxidative medicine and cellular longevity · 2019Article
- A connexin43/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation.Cell death and differentiation · 2018Article
- Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions.Acta neuropathologica · 2017Article
- Persistent Unresolved Inflammation in theMediators of inflammation · 2017Article
- Oxidative Stress and Neurobiology of Demyelination.Molecular neurobiology · 2016Review
- Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders.International journal of molecular sciences · 2015Review
- Intercellular cross-talk in intracerebral hemorrhage.Brain research · 2015Review
- Iron entry in neurons and astrocytes: a link with synaptic activity.Frontiers in molecular neuroscience · 2015Review
- Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia.Journal of neuroinflammation · 2014Article
- Subclinical inflammatory status in Rett syndrome.Mediators of inflammation · 2014Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundAstrocytes respond to local insults within the brain and the spinal cord with important changes in their phenotype. This process, overall known as "activation", is observed upon proinflammatory stimulation and leads astrocytes to acquire either a detrimental phenotype, thereby contributing to the neurodegenerative process, or a protective phenotype, thus supporting neuronal survival. Within the mechanisms responsible for inflammatory neurodegeneration, oxidative stress plays a major role and has recently been recognized to be heavily influenced by changes in cytosolic iron levels. In this work, we investigated how activation affects the competence of astrocytes to handle iron overload and the ensuing oxidative stress.
methodsCultures of pure cortical astrocytes were preincubated with proinflammatory cytokines (interleukin-1β and tumor necrosis factor α) or conditioned medium from lipopolysaccharide-activated microglia to promote activation and then exposed to a protocol of iron overload.
resultsWe demonstrate that activated astrocytes display an efficient protection against iron-mediated oxidative stress and cell death. Based on this evidence, we performed a comprehensive biochemical and molecular analysis, including a transcriptomic approach, to identify the molecular basis of this resistance.
conclusionsWe propose the protective phenotype acquired after activation not to involve the most common astrocytic antioxidant pathway, based on the Nrf2 transcription factor, but to result from a complex change in the expression and activity of several genes involved in the control of cellular redox state.
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