ArticlePhysical review letters2013
Periodic migration in a physical model of cells on micropatterns.
Article in Physical review letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 88 citations in OpenAlex.
- Deposited footprints let cells switch between confined, oscillatory, and exploratory migration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- Mesenchymal cell migration on one-dimensional micropatterns.Frontiers in cell and developmental biology · 2024Review
- Generation of a Virtual Cell using a Phase Field Approach to Model Amoeboid Crawling.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Coupling cell shape and velocity leads to oscillation and circling in keratocyte galvanotaxis.Biophysical journal · 2023Article
- Picking winners in cell-cell collisions: Wetting, speed, and contact.Physical review. E · 2022Article
- Sensing the shape of a cell with reaction diffusion and energy minimization.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Self-organization in amoeboid motility.Frontiers in cell and developmental biology · 2022Review
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Stick-slip model for actin-driven cell protrusions, cell polarization, and crawling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy.Science (New York, N.Y.) · 2020Article
- Article
- Article
- Article
- A minimal computational model for three-dimensional cell migration.Journal of the Royal Society, Interface · 2019Article
- Article
- On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility.Molecular biology of the cell · 2018Article
- Microdomain formation is a general property of bacterial membrane proteins and induces heterogeneity of diffusion patterns.BMC biology · 2018Article
- Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility.APL bioengineering · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We extend a model for the morphology and dynamics of a crawling eukaryotic cell to describe cells on micropatterned substrates. This model couples cell morphology, adhesion, and cytoskeletal flow in response to active stresses induced by actin and myosin. We propose that protrusive stresses are only generated where the cell adheres, leading to the cell's effective confinement to the pattern. Consistent with experimental results, simulated cells exhibit a broad range of behaviors, including steady motion, turning, bipedal motion, and periodic migration, in which the cell crawls persistently in one direction before reversing periodically. We show that periodic motion emerges naturally from the coupling of cell polarization to cell shape by reducing the model to a simplified one-dimensional form that can be understood analytically.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.