ArticleBehavioral and brain functions : BBF2013
The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia.
Article in Behavioral and brain functions : BBF, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes.Schizophrenia bulletin · 2015Pooled it
- CCDC68 predicts poor prognosis in patients with colorectal cancer: a study based on TCGA data.Journal of gastrointestinal oncology · 2022Article
- mRNA Expression of the CUB and Sushi Multiple Domains 1 (ACS omega · 2021Article
- Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.Scientific reports · 2021Article
- The phenotypic and genetic spectrum of patients with heterozygous mutations in cyclin M2 (CNNM2).Human mutation · 2021Article
- Shaping the Trans-Scale Properties of SchizophreniaFrontiers in human neuroscience · 2021Review
- Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients.BMC psychiatry · 2019Article
- A 1.5-Year Longitudinal Study of Social Activity in Patients With Schizophrenia.Frontiers in psychiatry · 2019Article
- Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment.Molecular psychiatry · 2018Article
- Cerebellar activation during a motor task in conversion disorder with motor paralysis: A case report and fMRI study.Neuropsychopharmacology reports · 2018Article
- Role of subcortical structures on cognitive and social function in schizophrenia.Scientific reports · 2018Article
- A Brief Assessment of Intelligence Decline in Schizophrenia As Represented by the Difference between Current and Premorbid Intellectual Quotient.Frontiers in psychiatry · 2017Review
- Cognitive clustering in schizophrenia patients, their first-degree relatives and healthy subjects is associated with anterior cingulate cortex volume.NeuroImage. Clinical · 2017Article
- Perinatal Asphyxia in Rat Alters Expression of Novel Schizophrenia Risk Genes.Frontiers in molecular neuroscience · 2017Article
- Genetic Variants in CSMD1 Gene Are Associated with Cognitive Performance in Normal Elderly Population.Genetics research international · 2017Article
- No association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.BMC psychiatry · 2016Article
- Human CNNM2 is not a Mg(2+) transporter per se.Pflugers Archiv : European journal of physiology · 2016Article
- Imaging genetics and psychiatric disorders.Current molecular medicine · 2015Review
- Common variants at 1p36 are associated with superior frontal gyrus volume.Translational psychiatry · 2014Article
- Perineuronal nets and schizophrenia: the importance of neuronal coatings.Neuroscience and biobehavioral reviews · 2014Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenome-wide significant associations of schizophrenia with eight SNPs in the CNNM2, MIR137, PCGEM1, TRIM26, CSMD1, MMP16, NT5C2 and CCDC68 genes have been identified in a recent mega-analysis of genome-wide association studies. To date, the role of these SNPs on gray matter (GM) volumes remains unclear.
methodsAfter performing quality control for minor-allele frequency > 5% using a JPT HapMap sample and our sample, a genotyping call rate > 95% and Hardy-Weinberg equilibrium testing (p > 0.01), five of eight SNPs were eligible for analysis. We used a comprehensive voxel-based morphometry (VBM) technique to investigate the effects of these five SNPs on GM volumes between major-allele homozygotes and minor-allele carriers in Japanese patients with schizophrenia (n = 173) and healthy subjects (n = 449).
resultsThe rs7914558 risk variant at CNNM2 was associated with voxel-based GM volumes in the bilateral inferior frontal gyri (right T = 4.96, p = 0.0088, left T = 4.66, p = 0.031). These peak voxels, which were affected by the variant, existed in the orbital region of the inferior frontal gyri. Individuals with the risk G/G genotype of rs7914558 had smaller GM volumes in the bilateral inferior frontal gyri than carriers of the non-risk A-allele. Although several effects of the genotype and the genotype-diagnosis interaction of other SNPs on GM volumes were observed in the exploratory VBM analyses, these effects did not remain after the FWE-correction for multiple tests (p > 0.05).
conclusionsOur findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the GM volumetric vulnerability of the orbital regions in the inferior frontal gyri.
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