Trial reportBlood2013
Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.
Trial report in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age.Genome medicine · 2025Article
- Cross-tissue comparison of epigenetic aging clocks in humans.Aging cell · 2025Article
- A systematic evaluation of cell-type-specific differential methylation analysis in bulk tissue.Briefings in bioinformatics · 2025Article
- Article
- Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress.Epigenetics · 2023Article
- Article
- Article
- Epigenetics in IBD: a conceptual framework for disease pathogenesis.Frontline gastroenterology · 2022Article
- Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer.Molecular medicine (Cambridge, Mass.) · 2021Article
- Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites.BMC biology · 2020Article
- ANCA autoantigen gene expression highlights neutrophil heterogeneity where expression in normal-density neutrophils correlates with ANCA-induced activation.Kidney international · 2020Article
- MethylResolver-a method for deconvoluting bulk DNA methylation profiles into known and unknown cell contents.Communications biology · 2020Article
- Understanding the Relevance of DNA Methylation Changes in Immune Differentiation and Disease.Genes · 2020Review
- Neutrophils in innate immunity and systems biology-level approaches.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Article
- Androgen receptor gene methylation related to colorectal cancer risk.Endocrine connections · 2019Article
- The value of blood derived DNA methylation signatures in advancing our understanding of Crohn's Disease pathogenesis.Translational gastroenterology and hepatology · 2019Article
- Identification of differentially methylated cell types in epigenome-wide association studies.Nature methods · 2018Article
- From forensic epigenetics to forensic epigenomics: broadening DNA investigative intelligence.Genome biology · 2017Article
- DNA methylation assessment from human slow- and fast-twitch skeletal muscle fibers.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Gene-Specific DNA Methylation Changes Predict Remission in Patients with ANCA-Associated Vasculitis.Journal of the American Society of Nephrology : JASN · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
DNA methylation is an important mechanism by which gene transcription and hence cellular function are regulated. Here, we provide detailed functional genome-wide methylome maps of 5 primary peripheral blood leukocyte subsets including T cells, B cells, monocytes/macrophages, and neutrophils obtained from healthy individuals. A comparison of these methylomes revealed highly specific cell-lineage and cell-subset methylation profiles. DNA hypomethylation is known to be permissive for gene expression and we identified cell-subset-specific hypomethylated regions (HMRs) that strongly correlate with gene transcription levels suggesting these HMRs may regulate corresponding cell functions. Single-nucleotide polymorphisms associated with immune-mediated disease in genome-wide association studies preferentially localized to these cell-specific regulatory HMRs, offering insight into pathogenesis by highlighting cell subsets in which specific epigenetic changes may drive disease. Our data provide a valuable reference tool for researchers aiming to investigate the role of DNA methylation in regulating primary leukocyte function in health and immune-mediated disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.