ArticleAdvances in experimental medicine and biology2014
Coarse-grained molecular dynamics provides insight into the interactions of lipids and cholesterol with rhodopsin.
Article in Advances in experimental medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- The Evolution of Lipids from Solvents to Substrates.Annual review of biophysics · 2026Review
- How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs).Cold Spring Harbor perspectives in biology · 2023Review
- In Silico Identification of Cholesterol Binding Motifs in the Chemokine Receptor CCR3.Membranes · 2021Article
- Lipid-Protein Interactions Are a Unique Property and Defining Feature of G Protein-Coupled Receptors.Biophysical journal · 2020Article
- Reconstruction of apo A2A receptor activation pathways reveal ligand-competent intermediates and state-dependent cholesterol hotspots.Scientific reports · 2019Article
- Quantum Mechanical and Molecular Mechanics Modeling of Membrane-Embedded Rhodopsins.The Journal of membrane biology · 2019Review
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Interfacial Binding Sites for Cholesterol on G Protein-Coupled Receptors.Biophysical journal · 2019Article
- Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions.PLoS computational biology · 2019Article
- Interaction of POPC, DPPC, and POPE with the μ opioid receptor: A coarse-grained molecular dynamics study.PloS one · 2019Article
- A sumatriptan coarse-grained model to explore different environments: interplay with experimental techniques.European biophysics journal : EBJ · 2018Article
- Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins.ACS central science · 2018Article
- Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol.PLoS computational biology · 2018Article
- Lipids Alter Rhodopsin Function via Ligand-like and Solvent-like Interactions.Biophysical journal · 2018Article
- Mechanism of allosteric regulation of βeLife · 2016Article
- Cholesterol-dependent Conformational Plasticity in GPCR Dimers.Scientific reports · 2016Article
- LipidWrapper: an algorithm for generating large-scale membrane models of arbitrary geometry.PLoS computational biology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Protein function is a complicated interplay between structure and dynamics, which can be heavily influenced by environmental factors and conditions. This is particularly true in the case of membrane proteins, such as the visual receptor rhodopsin. It has been well documented that lipid headgroups, polyunsaturated tails, and the concentration of cholesterol in membranes all play a role in the function of rhodopsin. Recently, we used all-atom simulations to demonstrate that different lipid species have preferential interactions and possible binding sites on rhodopsin's surface, consistent with experiment. However, the limited timescales of the simulations meant that the statistical uncertainty of these results was substantial. Accordingly, we present here 32 independent 1.6 μs coarse-grained simulations exploring lipids and cholesterols surrounding rhodopsin and opsin, in lipid bilayers mimicking those found naturally. Our results agree with those found experimentally and in previous simulations, but with far better statistical certainty. The results demonstrate the value of combining all-atom and coarse-grained models with experiment to provide a well-rounded view of lipid-protein interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.