ArticleJournal of molecular neuroscience : MN2014
Hsa-miR-132 regulates apoptosis in non-small cell lung cancer independent of acetylcholinesterase.
Article in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Systematic review and meta-analysis of the prognostic significance of microRNAs related to metastatic and EMT process among prostate cancer patients.Journal of translational medicine · 2021Pooled it
- Two Fluorescent Probes for Recognition of Acetylcholinesterase: Design, Synthesis, and Comparative Evaluation.Molecules (Basel, Switzerland) · 2024Article
- miR-124 as a Liquid Biopsy Prognostic Biomarker in Small Extracellular Vesicles from NSCLC Patients.International journal of molecular sciences · 2023Article
- Expression profiles of miR-196, miR-132, miR-146a, and miR-134 in human colorectal cancer tissues in accordance with their clinical significance : Comparison regarding KRAS mutation.Wiener klinische Wochenschrift · 2021Article
- Acetylcholinesterase and human cancers.Advances in cancer research · 2021Review
- Hesperidin administration suppresses the proliferation of lung cancer cells by promoting apoptosis via targeting the miR‑132/ZEB2 signalling pathway.International journal of molecular medicine · 2020Article
- Acetylcholine signaling system in progression of lung cancers.Pharmacology & therapeutics · 2019Review
- MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1.Acta pharmacologica Sinica · 2018Article
- miR-132 suppresses the migration and invasion of lung cancer cells by blocking USP9X-induced epithelial-mesenchymal transition.American journal of translational research · 2018Article
- A Novel Pak1/ATF2/miR-132 Signaling Axis Is Involved in the Hematogenous Metastasis of Gastric Cancer Cells.Molecular therapy. Nucleic acids · 2017Article
- Preliminary evaluation of circulating microRNAs as potential biomarkers in paracoccidioidomycosis.Biomedical reports · 2017Article
- Down-Regulation of microRNA-132 is Associated with Poor Prognosis of Colorectal Cancer.Annals of surgical oncology · 2016Article
- Downregulation of microRNA-132 indicates progression in hepatocellular carcinoma.Experimental and therapeutic medicine · 2016Article
- MicroRNA-132 targets PEA-15 and suppresses the progression of astrocytoma in vitro.Journal of neuro-oncology · 2016Article
- miR-132 mediates a metabolic shift in prostate cancer cells by targeting Glut1.FEBS open bio · 2016Article
- miR-132 targeting E2F5 suppresses cell proliferation, invasion, migration in ovarian cancer cells.American journal of translational research · 2016Article
- An Encapsulation of Gene Signatures for Hepatocellular Carcinoma, MicroRNA-132 Predicted Target Genes and the Corresponding Overlaps.PloS one · 2016Article
- The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice.International journal of ophthalmology · 2015Article
- Upregulation of miR-132 expression in glioma and its clinical significance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Journal of molecular neuroscience: impacting our brains.Journal of molecular neuroscience : MN · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MiR-132 is enriched in the central nerve system and is thought to be involved in neuronal development, maturation and function, and to be associated with several neurological disorders including Alzheimer's disease. In addition to its documented neuronal functions, an emerging role for miR-132 in tumorigenesis has been suggested. Recently, hsa-miR-132 was shown to be modulated in different tumor types. However, its role in non-small cell lung cancer (NSCLC) remains unclear. Here, we show that hsa-miR-132 can initiate apoptosis in NSCLC cells to dramatically attenuate tumor formation in nude mice independent of its effect on the proliferation/apoptosis-associated gene, acetylcholinesterase (AChE). Interestingly, hsa-miR-132 has no pro-apoptotic effect in normal pulmonary trachea epithelium. Taken together, these results suggest that hsa-miR-132 represses NSCLC growth by inducing apoptosis independent of AChE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.