ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2013
EGCG inhibit chemical reactivity of iron through forming an Ngal-EGCG-iron complex.
Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- ROS-responsive EGCG-Fe-Cur nanosystems for radioprotection through antioxidant and inhibition of ferroptosis pathways.Journal of nanobiotechnology · 2026Article
- EGCG Alleviates DSS-Induced Colitis by Inhibiting Ferroptosis Through the Activation of the Nrf2-GPX4 Pathway and Enhancing Iron Metabolism.Nutrients · 2025Article
- Role of lipocalin-2 in amyotrophic lateral sclerosis.Frontiers in aging neuroscience · 2025Review
- Identification and comparison of protein composition of biofilms in response to EGCG fromBiofilm · 2024Article
- Iron Dyshomeostasis in COVID-19: Biomarkers Reveal a Functional Link to 5-Lipoxygenase Activation.International journal of molecular sciences · 2022Article
- Polyphenols and Their Metabolites in Renal Diseases: An Overview.Foods (Basel, Switzerland) · 2022Review
- Discovery of Camellia sinensis catechins as SARS-CoV-2 3CL protease inhibitors through molecular docking, intra and extra cellular assays.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2022Article
- Effects of green tea extract treatment on erythropoiesis and iron parameters in iron-overloaded β-thalassemic mice.Frontiers in physiology · 2022Article
- Neuroprotective Properties of Green Tea (Molecules (Basel, Switzerland) · 2020Review
- Protective Effects of Epigallocatechin-3-Gallate from Green Tea in Various Kidney Diseases.Advances in nutrition (Bethesda, Md.) · 2019Article
- A Review of the Antiviral Role of Green Tea Catechins.Molecules (Basel, Switzerland) · 2017Review
- Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease.Molecules (Basel, Switzerland) · 2017Review
- Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice.The Journal of nutritional biochemistry · 2017Article
- Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis.Cellular and molecular gastroenterology and hepatology · 2016Article
- Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG).Nutrition journal · 2016Review
- Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2016Article
- Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regulation by Dietary Iron and Lipocalin 2 in Murine Model of Gut Inflammation.The American journal of pathology · 2016Article
- TMDB: a literature-curated database for small molecular compounds found from tea.BMC plant biology · 2014Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Accumulated evidence indicates that the interconversion of iron between ferric (Fe(3+)) and ferrous (Fe(2+)) can be realized through interaction with reactive oxygen species in the Fenton and Haber-Weiss reactions and thereby physiologically effects redox cycling. The imbalance of iron and ROS may eventually cause tissue damage such as renal proximal tubule injury and necrosis. Many approaches were exploited to ameliorate the oxidative stress caused by the imbalance. (-)-Epigallocatechin-3-gallate, the most active and most abundant catechin in tea, was found to be involved in the protection of a spectrum of renal injuries caused by oxidative stress. Most of studies suggested that EGCG works as an antioxidant. In this paper, Multivariate analysis of the LC-MS data of tea extracts and binding assays showed that the tea polyphenol EGCG can form stable complex with iron through the protein Ngal, a biomarker of acute kidney injury. UV-Vis and Luminescence spectrum methods showed that Ngal can inhibit the chemical reactivity of iron and EGCG through forming an Ngal-EGCG-iron complex. In thinking of the interaction of iron and ROS, we proposed that EGCG may work as both antioxidant and Ngal binding siderphore in protection of kidney from injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.