ArticleInternational journal of colorectal disease2014
Brain metastases from colorectal cancer: main clinical factors conditioning outcome.
Article in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Survival Outcome of Surgical Resection vs. Radiotherapy in Brain Metastasis From Colorectal Cancer: A Meta-Analysis.Frontiers in medicine · 2022Pooled it
- A systematic review to assess the management of patients with cerebral metastases secondary to colorectal cancer.Techniques in coloproctology · 2017Pooled it
- Systematic review: brain metastases from colorectal cancer--Incidence and patient characteristics.BMC cancer · 2016Pooled it
- Immune architecture of colorectal cancer brain metastases: spatial TAM heterogeneity and PD-L1 dynamics.Frontiers in immunology · 2026Article
- Colorectal cancer metastasis to the brain: A scoping review of incidence, treatment, and outcomes.World journal of gastrointestinal pathophysiology · 2025Article
- Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis.Oncology letters · 2025Article
- Prognostic factors associated with the transition in treatment methods for brain metastases from colorectal cancer.International journal of clinical oncology · 2023Article
- Where Are We Now and Where Might We Be Headed in Understanding and Managing Brain Metastases in Colorectal Cancer Patients?Current treatment options in oncology · 2022Review
- Review
- Factors Prognostic for Brain Metastases from Colorectal Cancer: A Single-Center Experience in China.Cancer management and research · 2021Article
- Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA).Radiation oncology (London, England) · 2020Article
- The Choice of Local Treatment Modalities for Patients with Brain Metastases from Digestive Cancers.Journal of oncology · 2019Article
- Novel graded prognostic assessment for colorectal cancer patients with brain metastases.International journal of clinical oncology · 2018Article
- Brain metastases in colorectal cancer: prognostic factors and survival analysis.International journal of colorectal disease · 2018Article
- Brain metastasis from colorectal cancer: a single center experience.Annals of surgical treatment and research · 2018Article
- Genetic variants associated with colorectal brain metastases susceptibility and survival.The pharmacogenomics journal · 2017Article
- Colorectal cancer metastatic to the brain: analysis of prognostic factors and impact of KRAS mutations on presentation and outcome.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Article
- Central nervous system metastasis secondary to colorectal cancer: a retrospective cohort study of 20 cases.Ecancermedicalscience · 2016Review
- Prognostic factors and multidisciplinary treatment modalities for brain metastases from colorectal cancer: analysis of 93 patients.BMC cancer · 2015Article
- Unusual osseous metastases from rectal adenocarcinoma: a case report and review of the literature.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of our study is to evaluate the outcome of patients affected by brain metastases from colorectal cancer and to correlate the outcome with prognostic factors.
methodsPatients were retrospectively evaluated. Survival distributions were estimated by using the Kaplan-Meier method. The log-rank test was used to assess the impact on survival of individual factors.
resultsAmong 41 patients (25M and 16F; median age 58), 58.5 % had rectal cancer and 39 % synchronous metastatic disease; 95 % had extracranial metastases, most common site was lung (87.8 %). Seven patients had synchronous brain metastases. Median overall survival after diagnosis of brain metastases was 5 months [95 % confidence interval 3-12 months]. Median survival from brain metastases diagnosis was 4.2 months in patients treated with radiotherapy (29.3 %), 11.9 months in those with radio- and chemotherapy (21.9 %) and 21.4 months in those with surgery with/without radiotherapy or chemotherapy (29.3 %) (P < 0.0001). On multivariate analysis, no independent prognostic factors were found for disease-free interval from diagnosis to brain metastases and overall survival; amount of chemotherapy before brain metastases have no statistically significant relation to brain-metastases-free-interval even if patients who received more than one line of chemotherapy have a longer median brain-metastases-free-interval than those who received less than one. KRAS was found mutated in 17/28 patients without statistically significant correlation to outcome due to the small sample size.
conclusionsPrognosis of brain-metastases-patients is poor. An interesting tool is to evaluate the correlation of KRAS status and brain metastases with aim to tailor treatment and follow-up.
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