ArticleBioinformatics (Oxford, England)2014
Mouse model phenotypes provide information about human drug targets.
Article in Bioinformatics (Oxford, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Expanding and refining the Mammalian Phenotype Ontology to enhance disease model discovery.Disease models & mechanisms · 2025Article
- A Rule-Based Inference Framework to Explore and Explain the Biological Related Mechanisms of Potential Drug-Drug Interactions.Computational and mathematical methods in medicine · 2022Article
- Ebsulfur and Ebselen as highly potent scaffolds for the development of potential SARS-CoV-2 antivirals.Bioorganic chemistry · 2021Article
- Towards FAIR protocols and workflows: the OpenPREDICT use case.PeerJ. Computer science · 2020Article
- BioHackathon 2015: Semantics of data for life sciences and reproducible research.F1000Research · 2020Article
- PathoPhenoDB, linking human pathogens to their phenotypes in support of infectious disease research.Scientific data · 2019Article
- The anatomy of phenotype ontologies: principles, properties and applications.Briefings in bioinformatics · 2018Article
- Ontology-based validation and identification of regulatory phenotypes.Bioinformatics (Oxford, England) · 2018Article
- Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment.Oncogene · 2018Article
- Of Men and Mice: Modeling the Fragile X Syndrome.Frontiers in molecular neuroscience · 2018Article
- Integrating phenotype ontologies with PhenomeNET.Journal of biomedical semantics · 2017Article
- Neuro-symbolic representation learning on biological knowledge graphs.Bioinformatics (Oxford, England) · 2017Article
- Semantic prioritization of novel causative genomic variants.PLoS computational biology · 2017Article
- Drug repurposing for glioblastoma based on molecular subtypes.Journal of biomedical informatics · 2016Article
- A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects.PLoS computational biology · 2016Article
- The digital revolution in phenotyping.Briefings in bioinformatics · 2016Article
- Phenome-based gene discovery provides information about Parkinson's disease drug targets.BMC genomics · 2016Article
- Towards precision medicine-based therapies for glioblastoma: interrogating human disease genomics and mouse phenotypes.BMC genomics · 2016Article
- Biological Relevance and Therapeutic Potential of the Hypusine Modification System.The Journal of biological chemistry · 2015Article
- Analysis of the human diseasome using phenotype similarity between common, genetic, and infectious diseases.Scientific reports · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
motivationMethods for computational drug target identification use information from diverse information sources to predict or prioritize drug targets for known drugs. One set of resources that has been relatively neglected for drug repurposing is animal model phenotype.
resultsWe investigate the use of mouse model phenotypes for drug target identification. To achieve this goal, we first integrate mouse model phenotypes and drug effects, and then systematically compare the phenotypic similarity between mouse models and drug effect profiles. We find a high similarity between phenotypes resulting from loss-of-function mutations and drug effects resulting from the inhibition of a protein through a drug action, and demonstrate how this approach can be used to suggest candidate drug targets. AVAILABILITY AND IMPLEMENTATION: Analysis code and supplementary data files are available on the project Web site at https://drugeffects.googlecode.com.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.