ArticlePsychopharmacology2014
Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 105 citations in OpenAlex.
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration.Psychopharmacology · 2026Review
- Sex differences in compulsive alcohol drinking phenotypes: implications for decision-making and social behavior in a preclinical model.Psychopharmacology · 2026Article
- Ceftriaxone alters the gut microbiome composition and reduces alcohol intake in male and female Sprague-Dawley rats.Alcohol (Fayetteville, N.Y.) · 2024Article
- Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence.Psychopharmacology · 2024Article
- Individual Behavioral and Neural Predictors of Future Alcohol Drinking Behavior.Biological psychiatry · 2024Article
- A translational rodent model of individual differences in sensitivity to the aversive properties of ethanol.Alcohol, clinical & experimental research · 2024Article
- Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence.bioRxiv : the preprint server for biology · 2023Article
- Impact of fluoxetine preexposure on MDMA-induced taste avoidance in male and female rats.Experimental and clinical psychopharmacology · 2023Article
- Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats.Biology of sex differences · 2023Article
- A translational rodent model of individual differences in sensitivity to the aversive properties of ethanol.bioRxiv : the preprint server for biology · 2023Article
- Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice.Journal of neuroscience research · 2022Article
- Sex-related differences in pattern of ethanol drinking under the intermittent-access model and its impact on exploratory and anxiety-like behavior in Long-Evans rats.Alcoholism, clinical and experimental research · 2022Article
- Sex differences in affective states and association with voluntary ethanol intake in Sprague-Dawley rats.Psychopharmacology · 2022Article
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- Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder.Biological psychiatry · 2022Review
- Sex differences in cholinergic circuits and behavioral disruptions following chronic ethanol exposure with and without thiamine deficiency.Alcoholism, clinical and experimental research · 2021Article
- Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking.International journal of molecular sciences · 2021Review
- Studying Sex Differences in Rodent Models of Addictive Behavior.Current protocols · 2021Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleVulnerability to alcoholism is determined by many factors, including the balance of pleasurable vs. aversive alcohol-induced sensations: pleasurable sensations increase intake, while aversive sensations decrease it. Female sex and adolescent age are associated with lower sensitivity to intake-reducing effects and more rapid development of alcohol abuse.
objectivesThis study assessed voluntary drinking and the aversive effects of alcohol to determine whether these measures are inversely related across the sexes and development.
methodsVoluntary drinking of 20 % ethanol in an every-other-day (EOD) availability pattern and the dose-response relationship of ethanol conditioned taste aversion (CTA) were assessed in male and female adolescent and adult rats.
resultsCTA was sex specific in adult but not adolescent rats, with adult females exhibiting less aversion. Voluntary ethanol consumption varied according to age and individual differences but was not sex specific. Adolescents initially drank more than adults, exhibited greater day-to-day variation in consumption, were more susceptible to the alcohol deprivation effect, and took longer to establish individual differences in consumption patterns.
conclusionsThese results show that the emergence of intake patterns differs between adolescents and adults. Adolescents as a group initiate drinking at high levels but decrease intake as they mature. A subset of adolescents maintained high drinking levels into adulthood. In contrast, most adults consumed at steady, low levels, but a small subset quickly established and maintained high-consumption patterns. Adolescents also showed marked deprivation-induced increases. Sex differences were not observed in EOD drinking during either adolescence or adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.