ArticleProceedings of the National Academy of Sciences of the United States of America2013
Pheromone discrimination by a pH-tuned polymorphism of the Bombyx mori pheromone-binding protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Heterologous expression, structural analysis, and functional characterization of Ostrinia nubilalis pheromone-binding protein 2 (OnubPBP2).Scientific reports · 2026Article
- Disrupting Pheromone Signaling in Insects: Design, Synthesis, and Evaluation of an Inhibitor.ACS omega · 2026Article
- Olfactory binding proteins: a review across the Insecta.Frontiers in zoology · 2025Review
- Transcriptome Profiling ofInternational journal of molecular sciences · 2025Article
- Identification of candidate chemosensory genes inFrontiers in physiology · 2024Article
- Olfactory Gene Families inInternational journal of molecular sciences · 2022Article
- Ostrinia furnacalis PBP2 solution NMR structure: Insight into ligand binding and release mechanisms.Protein science : a publication of the Protein Society · 2022Article
- Odorant Binding Proteins (OBPs) and Odorant Receptors (ORs) of Anopheles stephensi: Identification and comparative insights.PloS one · 2022Article
- Insights Into Chemosensory Proteins From Non-Model Insects: Advances and Perspectives in the Context of Pest Management.Frontiers in physiology · 2022Review
- The 40-Year Mystery of Insect Odorant-Binding Proteins.Biomolecules · 2021Review
- Crystal structure of Epiphyas postvittana pheromone binding protein 3.Scientific reports · 2020Article
- The Drosophila odorant-binding protein 28a is involved in the detection of the floral odour ß-ionone.Cellular and molecular life sciences : CMLS · 2020Article
- Genomic content of chemosensory genes correlates with host range in wood-boring beetles (Dendroctonus ponderosae, Agrilus planipennis, and Anoplophora glabripennis).BMC genomics · 2019Article
- Odorant Receptors and Odorant-Binding Proteins as Insect Pest Control Targets: A Comparative Analysis.Frontiers in physiology · 2018Review
- Selectivity and ligand-based molecular modeling of an odorant-binding protein from the leaf beetle Ambrostoma quadriimpressum (Coleoptera: Chrysomelidae) in relation to habitat-related volatiles.Scientific reports · 2017Article
- Binding affinity of five PBPs to Ostrinia sex pheromones.BMC molecular biology · 2017Article
- Structural insights into Cydia pomonella pheromone binding protein 2 mediated prediction of potentially active semiochemicals.Scientific reports · 2016Article
- Article
- The Peripheral Olfactory Repertoire of the Lightbrown Apple Moth, Epiphyas postvittana.PloS one · 2015Article
- Selectivity of odorant-binding proteins from the southern house mosquito tested against physiologically relevant ligands.Frontiers in physiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Bombyx mori pheromone-binding protein (BmorPBP) is known to adopt two different conformations. These are BmorPBP(A), where a regular helix formed by the C-terminal dodecapeptide segment, α7, occupies the ligand-binding cavity, and BmorPBP(B), where the binding site is free to accept ligands. NMR spectra of delipidated BmorPBP solutions at the physiological pH of the bulk sensillum lymph near pH 6.5 show only BmorPBP(A), and in mixtures, the two species are in slow exchange on the chemical shift frequency scale. This equilibrium has been monitored at variable pH and ligand concentrations, demonstrating that it is an intrinsic property of BmorPBP that is strongly affected by pH variation and ligand binding. This polymorphism tunes BmorPBP for optimal selective pheromone transport: Competition between α7 and lipophilic ligands for its binding cavity enables selective uptake of bombykol at the pore endings in the sensillum wall, whereas compounds with lower binding affinity can only be bound in the bulk sensillum lymph. After transport across the bulk sensillum lymph into the lower pH area near the dendritic membrane surface, bombykol is ejected near the receptor, whereas compounds with lower binding affinity are ejected before reaching the olfactory receptor, rendering them susceptible to degradation by enzymes present in the sensillum lymph.
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