ReviewJournal of mammary gland biology and neoplasia2014
The functional and molecular entities underlying amino acid and peptide transport by the mammary gland under different physiological and pathological conditions.
Review in Journal of mammary gland biology and neoplasia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- A Residual-Based Mathematical Approach to Evaluate Production-Adjusted Nitrogen Use Efficiency and Metabolic Responses in Dairy Cows.Veterinary sciences · 2026Article
- Impact of breast milk composition on nutritional status of term neonates with congenital heart defects: A prospective study.World journal of clinical pediatrics · 2026Article
- Integrating omics and functional data via representation learning to prioritize candidate genes for pleiotropic effect in dairy sheep.PNAS nexus · 2025Article
- Phenylalanine modulates casein synthesis in bovine mammary epithelial cells by influencing amino acid transport and protein synthesis pathways.Frontiers in nutrition · 2025Article
- Phenylalanine Regulates Milk Protein Synthesis via LAT1-mTOR Signaling Pathways in Bovine Mammary Epithelial Cells.International journal of molecular sciences · 2024Article
- Maternal dietary protein and amino acid intake is not associated with the amino acid composition of human milk in an affluent environment.The British journal of nutrition · 2024Observational
- Role of peptide transporters in small peptide uptake of bovine mammary epithelial cells cultured in a transwell chamber.Food science & nutrition · 2023Article
- Human Milk Lipids and Small Metabolites: Maternal and Microbial Origins.Metabolites · 2023Review
- Enhancing Milk Production by Nutrient Supplements: Strategies and Regulatory Pathways.Animals : an open access journal from MDPI · 2023Review
- Maternal stress is associated with higher protein-bound amino acid concentrations in human milk.Frontiers in nutrition · 2023Article
- Regulation of Milk Protein Synthesis by Free and Peptide-Bound Amino Acids in Dairy Cows.Biology · 2021Review
- Article
- Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.BMC genomics · 2018Article
- Arteriovenous blood metabolomics: An efficient method to determine the key metabolic pathway for milk synthesis in the intra-mammary gland.Scientific reports · 2018Article
- Regulation of amino acid transporters in the mammary gland from late pregnancy to peak lactation in the sow.Journal of animal science and biotechnology · 2018Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review describes the properties and regulation of the membrane transport proteins which supply the mammary gland with aminonitrogen to support metabolism under different physiological conditions (i.e. pregnancy, lactation and involution). Early studies focussed on characterising amino acid and peptide transport pathways with respect to substrate specificity, kinetics and hormonal regulation to allow a broad picture of the systems within the gland to be established. Recent investigations have concentrated on identifying the individual transporters at the molecular level (i.e. mRNA and protein). Many of the latter studies have identified the molecular correlates of the transport systems uncovered in the earlier functional investigations but in turn have also highlighted the need for more amino acid transport studies to be performed. The transporters function as either cotransporters and exchangers (or both) and act in a coordinated and regulated fashion to support the metabolic needs of the gland. However, it is apparent that a physiological role for a number of the transport proteins has yet to be elucidated. This article highlights the many gaps in our knowledge regarding the precise cellular location of a number of amino acid transporters within the gland. We also describe the role of amino acid transport in mammary cell volume regulation. Finally, the important role that individual mammary transport proteins may have in the growth and proliferation of mammary tumours is discussed.
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