Trial reportJournal of dental research2013
Release of bone markers in immediately loaded and nonloaded dental implants: a randomized clinical trial.
Trial report in Journal of dental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- May dental implant macro and microgeometry modifications influence peri-implant bone repair in smokers? A randomized clinical trial.BMC oral health · 2024Trial
- Comparison between inflammation-related markers in peri-implant crevicular fluid and clinical parameters during osseointegration in edentulous jaws.Clinical oral investigations · 2018Trial
- From Biological Mechanisms to Clinical Outcomes: A Scoping Review Comparing Immediate and Delayed Dental Implant Placement Protocols.Journal of clinical medicine · 2026Review
- Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice.Frontiers in molecular biosciences · 2022Review
- The all-on-four treatment concept: Systematic review.Journal of clinical and experimental dentistry · 2017Review
- Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study.International journal of implant dentistry · 2016Article
- Investigational clinical research in implant dentistry: beyond observational and descriptive studies.Journal of dental research · 2013Article
- Evaluation of Osteocalcin Level in Gingival Crevicular Fluid in Periodontal Intrabony Defects Treated with Autologous Platelet Rich Fibrin: Non-Randomized Experimental Study.Journal of oral & maxillofacial researchArticle
- Detection of Ostecalcin in gingival Crevicular fluid in a Group of Orthodontic Patients.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to compare the release of bone markers during osseointegration of immediately loaded and nonloaded implants. Forty patients who were indicated for rehabilitation with dental implants randomly received either implant and prosthesis placement within 72 hours (group IM) or implant insertion and no prosthesis placement (group NL). Peri-implant crevicular fluid was collected immediately after implant insertion and 7, 15, 30, 60, 90, and 120 days after surgery and levels of osteoprotegerin, transforming growth factors, osteocalcin, osteopontin, and parathyroid hormone were evaluated using Luminex assay. Bleeding index and peri-implantar sulcus depth were also evaluated. The data were compared using statistical tests (α = 5%). No statistical difference was found regarding demographic and clinical parameters (p > .05). Transforming growth factors, osteoprotegerin, osteopontin, and parathyroid hormone presented an earlier release peak in group IM than in NL group (p < .05). Osteocalcin achieved higher levels in group IM versus group NL between 7 and 30 days of evaluation (p < .05). It may be concluded that earlier loading positively modulates bone mediators release around immediately loaded implants when compared with nonloaded dental implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.