ArticleInternational journal of oral science2013
Botulinum toxin A inhibits salivary secretion of rabbit submandibular gland.
Article in International journal of oral science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Botulinum Toxin (Dysport) to Prevent Radiation-Induced Dysfunction of Salivary Glands in Head and Neck Cancer.Cancer reports (Hoboken, N.J.) · 2026Trial
- Trial
- [Research progress in diagnosis and treatment of non-tumorous salivary gland diseases].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Review
- Article
- Safety of High-Dose Botulinum Toxin Injections for Parotid and Submandibular Gland Radioprotection.Toxins · 2022Article
- Advances on mechanism and treatment of salivary gland in radiation injury.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Article
- Botulinum toxin type A interrupts autophagic flux of submandibular gland.Bioscience reports · 2019Article
- Autonomic reinnervation and functional regeneration in autologous transplanted submandibular glands in patients with severe keratoconjunctivitis sicca.International journal of oral science · 2018Article
- An Experimental Study on Botulinum Toxin Type A for the Treatment of Excessive Secretion after Submandibular Gland Transplantation in Rabbits.Journal of ophthalmology · 2016Article
- Microvascular autologous submandibular gland transplantation in severe cases of keratoconjunctivitis sicca.Maxillofacial plastic and reconstructive surgery · 2015Review
- Therapeutic use of botulinum toxin in migraine: mechanisms of action.British journal of pharmacology · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Botulinum toxin A (BTXA) has been used in several clinical trials to treat excessive glandular secretion; however, the precise mechanism of its action on the secretory function of salivary gland has not been fully elucidated. In this study, we aimed to investigate the effect of BTXA on secretion of submandibular gland in rabbits and to identify its mechanism of action on the secretory function of salivary gland. At 12 weeks after injection with 5 units of BTXA, we found a significant decrease in the saliva flow from submandibular glands, while the salivary amylase concentration increased. Morphological analysis revealed reduction in the size of acinar cells with intracellular accumulation of secretory granules that coalesced to form a large ovoid structure. Expression of M3-muscarinic acetylcholine receptor (M3 receptor) and aquaporin-5 (AQP5) mRNA decreased after BTXA treatment, and distribution of AQP5 in the apical membrane was reduced at 1, 2 and 4 weeks after BTXA injection. Furthermore, BTXA injection was found to induce apoptosis of acini. These results indicate that BTXA decreases the fluid secretion of submandibular glands and increases the concentration of amylase in saliva. Decreased expression of M3 receptor and AQP5, inhibition of AQP5 translocation, and cell apoptosis might involve in BTXA-reduced fluid secretion of submandibular glands.
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