ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2014
Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 95 citations in OpenAlex.
- Porcine intestinal goblet cells: Guardians of mucosal immunity and barrier function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Comment: Short-term benefit or long-term harm? Enteral antibiotics, intestinal inflammation, and immune trade-offs.Pediatric research · 2026Article
- Neonatal enteral antibiotics reduce gut inflammation and delay systemic immune development in preterm pigs.Pediatric research · 2026Article
- Effects of prenatal bifidobacterium supplementation on the gut microbiome in preterm infants of preeclamptic mothers.Journal of translational medicine · 2025Article
- Early antibiotic exposure and the risk of necrotizing enterocolitis in preterm neonates: insights from a large multicenter cohort in China.Pediatric research · 2025Article
- Review
- The association of early antibiotic exposure with subsequent development of late-onset sepsis in preterm infants: a systematic review and meta-analysis studies.International journal of emergency medicine · 2025Review
- A Case of Severe Early Childhood Caries Occurring in a Childhood Cancer Patient.Children (Basel, Switzerland) · 2025Article
- Umbilical arterial catheter duration as risk factor for Bell's Stage III necrotizing enterocolitis in preterm neonates.JPGN reports · 2024Article
- Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation.Scientific reports · 2024Article
- Neonatal prophylactic antibiotics after preterm birth affect plasma proteome and immune development in pigs.Pediatric research · 2023Article
- Determinants of microbial colonization in the premature gut.Molecular medicine (Cambridge, Mass.) · 2023Review
- Probiotics and Human Milk Differentially Influence the Gut Microbiome and NEC Incidence in Preterm Pigs.Nutrients · 2023Article
- Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets.Drug delivery and translational research · 2023Article
- Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review.Frontiers in pediatrics · 2023Review
- Article
- Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Drinking Water Supplemented with Acidifiers Improves the Growth Performance of Weaned Pigs and Potentially Regulates Antioxidant Capacity, Immunity, and Gastrointestinal Microbiota Diversity.Antioxidants (Basel, Switzerland) · 2022Article
- Effect of β-Glucan Supplementation on Growth Performance and Intestinal Epithelium Functions in Weaned Pigs Challenged by EnterotoxigenicAntibiotics (Basel, Switzerland) · 2022Article
- The Responses ofFrontiers in microbiology · 2022Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Preterm birth, bacterial colonization, and formula feeding predispose to necrotizing enterocolitis (NEC). Antibiotics are commonly administered to prevent sepsis in preterm infants, but it is not known whether this affects intestinal immunity and NEC resistance. We hypothesized that broad-spectrum antibiotic treatment improves NEC resistance and intestinal structure, function, and immunity in neonates. Caesarean-delivered preterm pigs were fed 3 days of parenteral nutrition followed by 2 days of enteral formula. Immediately after birth, they were assigned to receive either antibiotics (oral and parenteral doses of gentamycin, ampicillin, and metronidazole, ANTI, n = 11) or saline in the control group (CON, n = 13), given twice daily. NEC lesions and intestinal structure, function, microbiology, and immunity markers were recorded. None of the ANTI but 85% of the CON pigs developed NEC lesions by day 5 (0/11 vs. 11/13, P < 0.05). ANTI pigs had higher intestinal villi (+60%), digestive enzyme activities (+53-73%), and goblet cell densities (+110%) and lower myeloperoxidase (-51%) and colonic microbial density (10(5) vs. 10(10) colony-forming units, all P < 0.05). Microarray transcriptomics showed strong downregulation of genes related to inflammation and innate immune response to microbiota and marked upregulation of genes related to amino acid metabolism, in particular threonine, glucose transport systems, and cell cycle in 5-day-old ANTI pigs. In a follow-up experiment, 5 days of antibiotics prevented NEC at least until day 10. Neonatal prophylactic antibiotics effectively reduced gut bacterial load, prevented NEC, intestinal atrophy, dysfunction, and inflammation and enhanced expression of genes related to gut metabolism and immunity in preterm pigs.
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