ArticleNeuroscience2014
Neurosteroids modulate epileptiform activity and associated high-frequency oscillations in the piriform cortex.
Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- High-Frequency Oscillations and Epileptogenic Network.Current neuropharmacology · 2022Article
- Neurosteroids and Focal Epileptic Disorders.International journal of molecular sciences · 2020Review
- Carbonic anhydrase inhibition by acetazolamide reduces in vitro epileptiform synchronization.Neuropharmacology · 2015Article
- KCC2 function modulates in vitro ictogenesis.Neurobiology of disease · 2015Article
- Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats.Neurobiology of disease · 2015Article
- Neurosteroids differentially modulate fast and slow interictal discharges in the hippocampal CA3 area.The European journal of neuroscience · 2015Article
- Epileptiform synchronization and high-frequency oscillations in brain slices comprising piriform and entorhinal cortices.Neuroscience · 2014Article
- Limbic networks and epileptiform synchronization: the view from the experimental side.International review of neurobiology · 2014Review
- HFO to Measure Seizure Propensity and Improve Prognostication in Patients With Epilepsy.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Allotetrahydrodeoxycorticosterone (THDOC) belongs to a class of pregnane neurosteroidal compounds that enhance brain inhibition by interacting directly with GABAA signaling, mainly through an increase in tonic inhibitory current. Here, we addressed the role of THDOC in the modulation of interictal- and ictal-like activity and associated high-frequency oscillations (HFOs, 80-500 Hz; ripples: 80-200 Hz, fast ripples: 250-500 Hz) recorded in vitro in the rat piriform cortex, a highly excitable brain structure that is implicated in seizure generation and maintenance. We found that THDOC: (i) increased the duration of interictal discharges in the anterior piriform cortex while decreasing ictal discharge duration in both anterior and posterior piriform cortices; (ii) reduced the occurrence of HFOs associated to both interictal and ictal discharges; and (iii) prolonged the duration of 4-aminopyridine-induced, glutamatergic independent synchronous field potentials that are known to mainly result from the activation of GABAA receptors. Our results indicate that THDOC can modulate epileptiform synchronization in the piriform cortex presumably by potentiating GABAA receptor-mediated signaling. This evidence supports the view that neurosteroids regulate neuronal excitability and thus control the occurrence of seizures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.