Evidence map›Paper›PMID 24157583›Full record

ArticleLeukemia2014

Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia.

Y Kim, V P Schulz, N Satake, T A Gruber, A M Teixeira, S Halene, P G Gallagher, D S Krause

Abstract readCase ReportsLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Acute Megakaryocytic Leukemia.Cold Spring Harbor perspectives in medicine · 2020
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Y Kim1] Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA [2] Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
V P SchulzDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
N SatakeSection of Hematology/Oncology, Department of Pediatrics, University of California, Davis, Comprehensive Cancer Center, Sacramento, CA, USA.
T A Gruber1] Departments of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA [2] Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.
A M Teixeira1] Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA [2] Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA [3] Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
S HaleneYale Comprehensive Cancer Center, Division of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
P G Gallagher1] Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA [2] Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
D S Krause1] Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA [2] Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA [3] Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Barrier Insulators in ErythropoiesisR01HL106184 · NHLBI · YALE UNIVERSITY · PI GALLAGHER, PATRICK G · 2011 to 2014
$1.6M
MKL in megakaryocytopoiesisR01DK086267 · NIDDK · YALE UNIVERSITY · PI KRAUSE, DIANE S · 2010 to 2013
$1.5M
The role of fusion protein, OTT-MKL1, in acute megakaryoblastic leukemiaF32CA165683 · NCI · YALE UNIVERSITY · PI KIM, YEUN HEE · 2012 to 2012
$34k
NCI NIH HHS F32 CA165683NCI NIH HHS F32CA165683NCI NIH HHS P30 CA021765NHLBI NIH HHS R01 HL106184NHLBI NIH HHS R01HL106184NIDDK NIH HHS R01 DK086267
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chromosomes, Human, Pair 1Chromosomes, Human, Pair 22ExomeMutationTranslocation, GeneticChildDNA-Binding ProteinsHumansLeukemia, Megakaryoblastic, AcuteMaleMatrix Metalloproteinase 8Oncogene Proteins, FusionPolymorphism, Single NucleotideRNA-Binding ProteinsTrans-ActivatorsDNA-Binding ProteinsMatrix Metalloproteinase 8MMP8 protein, humanMRTFA protein, humanOncogene Proteins, FusionRBM15 protein, humanRNA-Binding ProteinsTrans-Activators

Identifiers

PMID24157583
PMCPMC3981934

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.