ArticleJournal of the American Academy of Child and Adolescent Psychiatry2013
A potential electroencephalography and cognitive biosignature for the child behavior checklist-dysregulation profile.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Early Predictors of the Childhood Dysregulation Profile: A Systematic Review.Clinical child and family psychology review · 2026Pooled it
- Moderators and mediators of the relationship between parental depression and children's emotion dysregulation: a systematic review.Frontiers in psychiatry · 2025Pooled it
- A Systematic Review on Feature Extraction in Electroencephalography-Based Diagnostics and Therapy in Attention Deficit Hyperactivity Disorder.Sensors (Basel, Switzerland) · 2022Pooled it
- Effects of d-Methylphenidate, Guanfacine, and Their Combination on Electroencephalogram Resting State Spectral Power in Attention-Deficit/Hyperactivity Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Trial
- Article
- Stage 2 Registered Report: The Bidirectional Relationship Between Brain Features and the Dysregulation Profile: A Longitudinal, Multimodal Approach.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Transdiagnostic indicators predict developmental changes in cognitive control resting-state networks.Development and psychopathology · 2023Article
- Frustration, Cognition, and Psychophysiology in Dysregulated Children: A Research Domain Criteria Approach.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Article
- Brain voxel-based morphometry correlates of emotion dysregulation in attention-deficit hyperactivity disorder.Brain imaging and behavior · 2021Article
- Parsing heterogeneity in attention-deficit hyperactivity disorder using EEG-based subgroups.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Identification of biotypes in Attention-Deficit/Hyperactivity Disorder, a report from a randomized, controlled trial.Personalized medicine in psychiatry · 2017Article
- Upregulated GABA Inhibitory Function in ADHD Children with Child Behavior Checklist-Dysregulation Profile: 123I-Iomazenil SPECT Study.Frontiers in psychiatry · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe Child Behavior Checklist-Dysregulation Profile (CBCL/DP) identifies youth at increased risk for significant psychopathology. Although the genetic architecture and several biological correlates of the CBCL/DP have been described, little work has elucidated its underlying neurobiology. We examined the potential utility of electroencephalography (EEG), along with behavioral and cognitive assessments, in differentiating individuals based on the CBCL/DP.
methodParticipants aged 7 to 14 years of age were categorized into 3 age- and sex-matched groups based on clinical assessment and CBCL/DP: typically developing controls without attention-deficit/hyperactivity disorder (ADHD) (n = 38), individuals with ADHD without the CBCL/DP (ADHD/DP-) (n = 38), and individuals with the CBCL/DP (CBCL/DP+) (n = 38). Groups were compared with EEG and measures of clinical phenomenology and cognition.
resultsADHD/DP- and CBCL/DP+ groups had increased inattention, but the CBCL/DP+ group had increased hyperactive/impulsive symptoms, disruptive behavior, mood, and anxiety comorbidities compared with the group with ADHD alone. Cognitive profiles suggested that ADHD/DP-participants had fast impulsive responses, whereas CBCL/DP+ participants were slow and inattentive. On EEG, CBCL/DP+ had a distinct profile of attenuated δ-band and elevated α-band spectral power in the central and parietal regions compared to ADHD/DP- and controls. The low-δ/high-α profile was correlated with measures of emotion and behavior problems and not with inattentive symptomatology or cognitive measures. There were no EEG differences between the ADHD/DP- and control groups.
conclusionsAn EEG/cognitive profile suggests a distinct pattern of underlying neural dysfunction with the CBCL/DP that might ultimately serve as a biosignature. Further work is required to identify potential relationships with clinically defined psychiatric disorders, particularly those of dysregulated mood.
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