ArticleBiological psychiatry2014
Functional t1ρ imaging in panic disorder.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Enhanced harm detection following maternal separation: Transgenerational transmission and reversibility by inhaled amiloride.Science advances · 2023Article
- Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder.Brain imaging and behavior · 2022Article
- Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function.Frontiers in aging neuroscience · 2022Article
- R1ρ sensitivity to pH and other compounds at clinically accessible spin-lock fields in the presence of proteins.NMR in biomedicine · 2020Article
- Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.Frontiers in psychiatry · 2020Review
- Comparison of TThe Journal of neuropsychiatry and clinical neurosciences · 2020Article
- Fear Network Model in Panic Disorder: The Past and the Future.Psychiatry investigation · 2019Article
- Conserved DNA Methylation Signatures in Early Maternal Separation and in Twins Discordant for COScientific reports · 2018Article
- Acid-sensing T cell death associated gene-8 receptor expression in panic disorder.Brain, behavior, and immunity · 2018Article
- Relationship altered between functional T1ρ and BOLD signals in bipolar disorder.Brain and behavior · 2017Article
- Functional neuroanatomy in panic disorder: Status quo of the research.World journal of psychiatry · 2017Article
- Panic Anxiety in Humans with Bilateral Amygdala Lesions: Pharmacological Induction via Cardiorespiratory Interoceptive Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Eccentricity mapping of the human visual cortex to evaluate temporal dynamics of functional T1ρ mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Acid-base dysregulation and chemosensory mechanisms in panic disorder: a translational update.Translational psychiatry · 2015Review
- Rapid acquisition strategy for functional T1ρ mapping of the brain.Magnetic resonance imaging · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAbnormal brain pH has been suggested to play a critical role in panic disorder. To investigate this possibility, we employed a pH-sensitive magnetic resonance (MR) imaging strategy (T1 relaxation in the rotating frame [T1ρ]) and conventional blood oxygen level-dependent (BOLD) imaging.
methodsThirteen panic disorder participants and 13 matched control subjects were enrolled in the study. T1ρ and BOLD were used to study the functional response to a visual flashing checkerboard and their relationship to panic symptoms assessed using the Beck Anxiety Inventory.
resultsIn response to visual stimulation, T1ρ imaging revealed a significantly greater increase in the visual cortex of panic disorder participants. T1ρ also detected a stimulus-evoked decrease in the anterior cingulate cortex. Blood oxygen level-dependent imaging detected no functional differences between groups. The correspondence between panic symptoms and functional T1ρ response identified significant relationships within the left inferior parietal lobe, left middle temporal gyrus, and right insula. No relationships were found between panic symptoms and the BOLD signal.
conclusionsThe data suggest greater activity-evoked T1ρ changes in the visual cortex and anterior cingulate cortex of panic disorder participants. These observations are consistent with a pH dysregulation in panic disorder. In addition, our data suggest that T1ρ imaging may provide information about panic disorder that is distinct from conventional BOLD imaging and may reflect abnormalities in pH and/or brain metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.