Evidence map›Paper›PMID 24156912›Full record

ArticleParkinsonism & related disorders2014

Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.

Jia Y Wan, Karen L Edwards, Carolyn M Hutter, Ignacio F Mata, Ali Samii, John W Roberts, Pinky Agarwal, Harvey Checkoway, Federico M Farin, Dora Yearout and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jia Y WanDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Karen L EdwardsDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Carolyn M HutterDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Ignacio F MataVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
Ali SamiiVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
John W RobertsVirginia Mason Medical Center, Seattle, WA, USA.
Pinky AgarwalBooth Gardner Parkinson's Care Center, Evergreen Hospital Medical Center, Kirkland, WA, USA.
Harvey CheckowayDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Federico M FarinDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Dora YearoutVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
Cyrus P ZabetianVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: zabetian@u.washington.edu.
University of Washington · USEvergreen Health Medical Center · USVA Puget Sound Health Care System · USVirginia Mason Medical Center · US

Funding

WILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI GALLAGHER, EVAN P · 1987 to 2021
$51.2M
Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
Using Multiplex Families to map Genes that Modify Susceptibility and Age at OnsetR01NS065070 · NINDS · UNIVERSITY OF WASHINGTON · PI ZABETIAN, CYRUS P · 2009 to 2012
$2.0M
Identification of Issues and Expectations of Subjects Participating in Genetic StR01CA149051 · NCI · UNIVERSITY OF WASHINGTON · PI EDWARDS, KAREN L · 2011 to 2013
$1.2M
Genetic Risk Factors for Parkinson's DiseaseI01BX000531 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI ZABETIAN, CYRUS P · 2009 to 2013
–
BLRD VA I01 BX000531NCI NIH HHS R01 CA149051NIEHS NIH HHS P42 ES004696NINDS NIH HHS P50 NS062684NINDS NIH HHS R01 NS065070
6 · The paper itself

Abstract

backgroundPrevious studies indicate that as many as six genes within the PARK10 region (RNF11, UQCRH, HIVEP3, EIF2B3, USP24, ELAVL4) might modify susceptibility or age at onset in Parkinson's disease (PD).

methodsWe sought to identify new PD susceptibility genes and to validate previously nominated candidate genes within the PARK10 region using a two-stage design. We used data from a large, publicly-available genome-wide association study (GWAS) in the discovery stage (n = 2000 cases and 1986 controls) and data from three independent studies for the replication stage (total n = 2113 cases and 2095 controls). Marker density was increased by imputation using HapMap 3 and 1000 Genomes reference panels, and over 40,000 single nucleotide polymorphisms (SNPs) were used in the final analysis. The association between each SNP and PD was modeled using logistic regression with an additive allele dosage effect and adjusted for sex, age, and axes of geographical variation.

resultsAlthough the discovery stage yielded promising findings for SNPs in several novel genes, including DAB1, none of the results were validated in the replication stage. Furthermore, in meta-analyses across all datasets no genes within PARK10 reached significance after accounting for multiple testing.

conclusionOur results suggest that common variation in the PARK10 region is not associated with PD risk. However, additional studies are needed to assess the role of PARK10 in modifying age at onset and to determine whether rare variants in this region might affect PD susceptibility.

Indexed as

AgedFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleParkinson DiseasePolymorphism, Single NucleotideGWASPARK10Parkinson's diseaseReplication

Identifiers

PMID24156912
PMCPMC3946853
OpenAlexW2126621406

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.