Observational studyCritical care (London, England)2013
Procalcitonin biomarker kinetics fails to predict treatment response in perioperative abdominal infection with septic shock.
Observational study in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- The Role and Importance of Procalcitonin (PCT) Testing in Rational Antibiotic Prescribing and Antibiotic Stewardship Programs.Immunity, inflammation and disease · 2026Review
- SeptAsTERS- SeptiCyte® RAPID as assessment tool for early recognition of sepsis - a prospective observational study.Infection · 2025Observational
- Importance of Source Control in the Subgroup of Intra-Abdominal Infections for Septic Shock Patients: Analysis of 390 Cases.Mediterranean journal of hematology and infectious diseases · 2024Article
- Management of Intra-Abdominal Infections: The Role of Procalcitonin.Antibiotics (Basel, Switzerland) · 2023Review
- A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review.The Eurasian journal of medicine · 2022Article
- Functional Characterization of Neutrophils Allows Source Control Evaluation in a Murine Sepsis Model.The Journal of surgical research · 2022Article
- The value of sepsis biomarkers and their kinetics in the prognosis of septic shock due to bacterial infections.Anaesthesiology intensive therapy · 2021Article
- Current progress of source control in the management of intra-abdominal infections.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2020Review
- An approach to antibiotic treatment in patients with sepsis.Journal of thoracic disease · 2020Review
- Procalcitonin: Where Are We Now?Critical care clinics · 2020Review
- [Procalcitonin as a tool for the assessment of successful therapy of severe sepsis : An analysis using clinical routine data].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Review
- Expression of the Long Intergenic Non-Coding RNA (lincRNA) of the NED25 Gene Modulates the microRNA-125b, STAT3, Nitric Oxide, and Procalcitonin Signaling Pathways in Patients with Sepsis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Is very short-course antibiotic therapy possible in postoperative intra-abdominal infections? Discussion on "Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial".Intensive care medicine · 2018Article
- The Predictive Role of Procalcitonin On the Treatment of Intra-Abdominal Infections.Open access Macedonian journal of medical sciences · 2017Article
- Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis.Annals of intensive care · 2017Article
- Serum Level of HMGB1 Protein and Inflammatory Markers in Patients with Secondary Peritonitis: Time Course and the Association with Clinical Status.Journal of medical biochemistry · 2017Article
- Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference.World journal of emergency surgery : WJES · 2017Review
- Duration of antibiotic therapy in the intensive care unit.Journal of thoracic disease · 2016Review
- Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).World journal of emergency surgery : WJES · 2016Review
- Inflammatory mediators in intra-abdominal sepsis or injury - a scoping review.Critical care (London, England) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionProcalcitonin (PCT) biomarker is suggested to tailor antibiotic therapy in the medical intensive care unit (ICU) but studies in perioperative medicine are scarce. The aim of this study was to determine whether PCT reported thresholds are associated with the initial treatment response in perioperative septic shock secondary to intra-abdominal infection.
methodsThis single ICU, observational study included patients with perioperative septic shocks secondary to intra-abdominal infection. Demographics, PCT at days 0, 1, 3, 5, treatment response and outcome were collected. Treatment failure included death related to the initial infection, second source control treatment or a new onset intra-abdominal infection. The primary endpoint was to assess whether PCT thresholds (0.5 ng/ml or a drop from the peak of at least 80%) predict the initial treatment response.
resultsWe included 101 consecutive cases. Initial treatment failed in 36 patients with a subsequent mortality of 75%. Upon admission, PCT was doubled when treatment ultimately failed (21.7 ng/ml ± 38.7 vs. 41.7 ng/ml ± 75.7; P = 0.04). Although 95% of the patients in whom PCT dropped down below 0.5 ng/ml responded to treatment, 50% of the patients in whom PCT remained above 0.5 ng/ml also responded successfully to treatment. Moreover, despite a PCT drop of at least 80%, 40% of patients had treatment failure.
conclusionsIn perioperative intra-abdominal infections with shock, PCT decrease to 0.5 ng/ml lacked sensitivity to predict treatment response and its decrease of at least 80% from its peak failed to accurately predict treatment response. Studies in perioperative severe infections are needed before using PCT to tailor antibiotic use in this population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.