ArticleLangmuir : the ACS journal of surfaces and colloids2013
Interaction between a cationic surfactant-like peptide and lipid vesicles and its relationship to antimicrobial activity.
Article in Langmuir : the ACS journal of surfaces and colloids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Amino acid-based surfactants: sustainable synthesis and antimicrobial mechanisms.Beilstein journal of organic chemistry · 2026Review
- Effect of Chirality and Amphiphilicity on the Antimicrobial Activity of Tripodal Lysine-Based Peptides.ACS applied bio materials · 2025Article
- Interaction of Arginine-Rich Surfactant-like Peptide Nanotubes with Liposomes.Biomacromolecules · 2024Article
- Development and characterization of lung surfactant-coated polymer nanoparticles for pulmonary drug delivery.Biomaterials advances · 2023Article
- Insights into Polyphenol-Lipid Interactions: Chemical Methods, Molecular Aspects and Their Effects on Membrane Structures.Plants (Basel, Switzerland) · 2022Review
- Interactions between Hydrolysable Tannins and Lipid Vesicles fromMolecules (Basel, Switzerland) · 2022Article
- Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives.Soft matter · 2021Review
- Review
- Selective Antibacterial Activity and Lipid Membrane Interactions of Arginine-Rich Amphiphilic Peptides.ACS applied bio materials · 2020Article
- Self-Assembly, Antimicrobial Activity, and Membrane Interactions of Arginine-Capped Peptide Bola-Amphiphiles.ACS applied bio materials · 2019Article
- Peptide-Stabilized Emulsions and Gels from an Arginine-Rich Surfactant-like Peptide with Antimicrobial Activity.ACS applied materials & interfaces · 2019Article
- Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives.Molecules (Basel, Switzerland) · 2019Review
- Self-assembly dynamics and antimicrobial activity of all l- and d-amino acid enantiomers of a designer peptide.Nanoscale · 2018Article
- Peptide self-assembly into lamellar phases and the formation of lipid-peptide nanostructures.Nano research · 2018Article
- Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility.Nano letters · 2016Article
- Self-assembling amphiphilic peptides.Journal of peptide science : an official publication of the European Peptide Society · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigate the properties of an antimicrobial surfactant-like peptide (Ala)6(Arg), A6R, containing a cationic headgroup. The interaction of this peptide with zwitterionic (DPPC) lipid vesicles is investigated using a range of microscopic, X-ray scattering, spectroscopic, and calorimetric methods. The β-sheet structure adopted by A6R is disrupted in the presence of DPPC. A strong effect on the small-angle X-ray scattering profile is observed: the Bragg peaks from the DPPC bilayers in the vesicle walls are eliminated in the presence of A6R and only bilayer form factor peaks are observed. All of these observations point to the interaction of A6R with DPPC bilayers. These studies provide insight into interactions between a model cationic peptide and vesicles, relevant to understanding the action of antimicrobial peptides on lipid membranes. Notably, peptide A6R exhibits antimicrobial activity without membrane lysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.