ArticleBMC genomics2013
The scale and evolutionary significance of horizontal gene transfer in the choanoflagellate Monosiga brevicollis.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Ancestral neuronal receptors are bacterial accessory toxins.Nature communications · 2026Article
- A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated KProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Old genes in new places: A taxon-rich analysis of interdomain lateral gene transfer events.PLoS genetics · 2022Article
- Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta.Scientific reports · 2021Article
- Modified base-binding EVE and DCD domains: striking diversity of genomic contexts in prokaryotes and predicted involvement in a variety of cellular processes.BMC biology · 2020Article
- A genomic survey of transposable elements in the choanoflagellateMobile DNA · 2019Article
- Review
- Alienness: Rapid Detection of Candidate Horizontal Gene Transfers across the Tree of Life.Genes · 2017Article
- Re-analyses of "Algal" Genes Suggest a Complex Evolutionary History of Oomycetes.Frontiers in plant science · 2017Article
- A role for diatom-like silicon transporters in calcifying coccolithophores.Nature communications · 2016Article
- Article
- Horizontal gene transfer: building the web of life.Nature reviews. Genetics · 2015Review
- Stable-isotope probing and metagenomics reveal predation by protozoa drives E. coli removal in slow sand filters.The ISME journal · 2015Article
- The cell survival pathways of the primordial RNA-DNA complex remain conserved in the extant genomes and may function as proto-oncogenes.European journal of microbiology & immunology · 2015Review
- Bacterial influences on animal origins.Cold Spring Harbor perspectives in biology · 2014Review
- Review
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is generally agreed that horizontal gene transfer (HGT) is common in phagotrophic protists. However, the overall scale of HGT and the cumulative impact of acquired genes on the evolution of these organisms remain largely unknown.
resultsChoanoflagellates are phagotrophs and the closest living relatives of animals. In this study, we performed phylogenomic analyses to investigate the scale of HGT and the evolutionary importance of horizontally acquired genes in the choanoflagellate Monosiga brevicollis. Our analyses identified 405 genes that are likely derived from algae and prokaryotes, accounting for approximately 4.4% of the Monosiga nuclear genome. Many of the horizontally acquired genes identified in Monosiga were probably acquired from food sources, rather than by endosymbiotic gene transfer (EGT) from obsolete endosymbionts or plastids. Of 193 genes identified in our analyses with functional information, 84 (43.5%) are involved in carbohydrate or amino acid metabolism, and 45 (23.3%) are transporters and/or involved in response to oxidative, osmotic, antibiotic, or heavy metal stresses. Some identified genes may also participate in biosynthesis of important metabolites such as vitamins C and K12, porphyrins and phospholipids.
conclusionsOur results suggest that HGT is frequent in Monosiga brevicollis and might have contributed substantially to its adaptation and evolution. This finding also highlights the importance of HGT in the genome and organismal evolution of phagotrophic eukaryotes.
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