ArticleRetrovirology2013
Natural regulatory T cells inhibit production of cytotoxic molecules in CD8⁺ T cells during low-level Friend retrovirus infection.
Article in Retrovirology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- T-cell immune status in patients with acute exacerbation of chronic obstructive pulmonary disease: a case-control study.Frontiers in medicine · 2025Article
- Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection.PLoS pathogens · 2019Article
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance.Cancer immunology, immunotherapy : CII · 2019Article
- Article
- Regulatory T cells in retroviral infections.PLoS pathogens · 2018Review
- Article
- Limited Foxp3Frontiers in immunology · 2018Article
- Helios + Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection.BMC immunology · 2017Article
- Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection.Scientific reports · 2017Article
- Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.Retrovirology · 2016Review
- Infiltrating regulatory B cells control neuroinflammation following viral brain infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- To drive or be driven: the path of a mouse model of recurrent pregnancy loss.Reproduction (Cambridge, England) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytotoxic T cells (CTL) play a central role in the control of viral infections. Their antiviral activity can be mediated by at least two cytotoxic pathways, namely the granule exocytosis pathway, involving perforin and granzymes, and the Fas-FasL pathway. It was shown that the level of Friend retrovirus (FV) replication determines the cytotoxic pathway for the control of viral infection. In low-level infection only the Fas pathway is active, whereas cytotoxic molecules are not produced. In the current study, we elucidate the role of CD4⁺ regulatory T cells (Tregs) in suppressing the exocytosis pathway during an asymptomatic low-level infection.
findingsWe show that even a low-level retrovirus infection induced a strong activation and proliferation of natural Tregs. The expanded Tregs suppressed the proliferation of virus-specific CD8⁺ T cells and the production of cytotoxic molecules by these cells. Not surprisingly, the in vivo killing activity of these CD8⁺ T cells was rather weak. Selective depletion of Foxp3⁺ Tregs resulted in de novo granzyme production and augmented virus-specific in vivo killing, but did not affect the low-level virus replication.
conclusionsExpanded natural Tregs determined the cytotoxic pathways of virus-specific effector CD8⁺ T cells during the acute phase of retroviral infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.