ArticleJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 532015
Psychophysiological responses to emotional stimuli in children and adolescents with autism and fragile X syndrome.
Article in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Autonomic Function in Fragile X Syndrome: A Systematic Review.Journal of intellectual disability research : JIDR · 2026Pooled it
- Emotion potentiated startle in fragile X syndrome.Journal of autism and developmental disorders · 2014Trial
- Social Behavior Forecasts Moment-to-Moment Changes in RSA in Infants With Autism.Developmental science · 2026Article
- The Brain, Body, and Behavior Dataset (BBBD): Multimodal Recordings during Educational Videos.Scientific data · 2026Article
- tVNS alters inflammatory response in adult VPA-induced mouse model of autism: evidence for sexual dimorphism.FEBS open bio · 2025Article
- Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study.Journal of autism and developmental disorders · 2024Article
- Sensory Gating in Neurodevelopmental Disorders: A Scoping Review.Research on child and adolescent psychopathology · 2023Article
- Observable Symptoms of Anxiety in Individuals with Fragile X Syndrome: Parent and Caregiver Perspectives.Genes · 2022Article
- Infant physiological activity and the early emergence of social communication.Developmental psychobiology · 2021Article
- Early behavioral and physiological markers of social anxiety in infants with fragile X syndrome.Journal of neurodevelopmental disorders · 2021Article
- Cardiac Startle Response and Clinical Outcomes in Preschool Children With Fragile X Syndrome and Autism Spectrum Disorder.Frontiers in psychiatry · 2021Article
- Trial-to-Trial Variability in Electrodermal Activity to Odor in Autism.Autism research : official journal of the International Society for Autism Research · 2020Article
- Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Physiological regulation and social-emotional processing in female carriers of the FMR1 premutation.Physiology & behavior · 2020Article
- Coupling of autism genes to tissue-wide expression and dysfunction of synapse, calcium signalling and transcriptional regulation.PloS one · 2020Article
- Sympathetic-Parasympathetic Interaction and Externalizing Problems in Children with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2019Article
- Differences in the Late Positive Potential and P300 to Emotional Faces in Individuals with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019Article
- Developmental trajectories of autonomic functioning in autism from birth to early childhood.Biological psychology · 2019Article
- Vagus nerve stimulation as a potential adjuvant to behavioral therapy for autism and other neurodevelopmental disorders.Journal of neurodevelopmental disorders · 2017Review
- Introduction to the Special Issue: Discrepancies in Adolescent-Parent Perceptions of the Family and Adolescent Adjustment.Journal of youth and adolescence · 2016Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Individuals with autism demonstrate atypical and variable responses to social and emotional stimuli, perhaps reflecting heterogeneity of the disorder. The goal of this study was to determine whether unique profiles of psychophysiological responses to such stimuli could be identified in individuals diagnosed with autism spectrum disorder (ASD), with fragile X syndrome (FXS), and with comorbid autism and fragile X syndrome (ASD + FXS), and in typically developing (TYP) individuals. This study included 52 boys (ages 10-17): idiopathic ASD (n = 12), FXS (n = 12), comorbid ASD + FXS (n = 17), and TYP (n = 11). Physiological responses, including potentiated startle, electrodermal response, heart rate variability, and vagal tone, were collected concurrently while participants viewed emotionally evocative pictures of human faces or nonsocial images. Although some of these measures have been utilized separately for investigations on these diagnostic groups, they have not been considered together. Results using Kruskal-Wallis one-way analysis of variance by ranks indicate statistically significant differences in distributions of autonomic regulation responses between groups. The most notable differences were between the ASD group and both the FXS groups on measures of sympathetic activity, with FXS groups evincing increased activity. Also, both the ASD and ASD + FXS groups showed significantly decreased parasympathetic activity compared with FXS and TYP groups. In addition, the ASD + FXS group demonstrated a unique distribution of startle potentiation and arousal modulation. This study provides evidence that autonomic arousal and regulation profiles could be useful for distinguishing subgroups of autism and shed light on the variability underlying emotional responsivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.