ArticleAmerican journal of respiratory cell and molecular biology2014
IL-5 induces suspended eosinophils to undergo unique global reorganization associated with priming.
Article in American journal of respiratory cell and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Biological functions and clinical efficacy of IL-5/IL-5Rα-targeted therapies across eosinophilia-associated diseases.Frontiers in immunology · 2026Review
- Mechanistic modelling of allergen-induced airways disease in early life.Scientific reports · 2025Article
- Effects of Lidocaine-Derived Organic Compounds on Eosinophil Activation and Survival.Molecules (Basel, Switzerland) · 2023Article
- Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes.Mucosal immunology · 2021Article
- Article
- Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil DeathFrontiers in immunology · 2021Article
- Possible Mechanisms of Eosinophil Accumulation in Eosinophilic Pneumonia.Biomolecules · 2020Review
- Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020Article
- Rho and Rac, but not ROCK, are required for secretion of human and mouse eosinophil-associated RNases.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- Myeloid-derived growth factor is a resident endoplasmic reticulum protein.The Journal of biological chemistry · 2018Article
- Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils.Journal of leukocyte biology · 2018Article
- Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating βThe Journal of allergy and clinical immunology · 2018Article
- Metabolic Profiling of Human Eosinophils.Frontiers in immunology · 2018Article
- Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin.PloS one · 2018Article
- Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge.International archives of allergy and immunology · 2018Article
- IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis.World journal of experimental medicine · 2017Review
- Eosinophil Activation Status in Separate Compartments and Association with Asthma.Frontiers in medicine · 2017Review
- Proteomics of Eosinophil Activation.Frontiers in medicine · 2017Review
- The Peripheral Blood Eosinophil Proteome.Journal of proteome research · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The experiments described herein define a unique program of polarization of suspended human eosinophils stimulated with IL-5 family cytokines. We found that eosinophil granules and the nucleus move in opposite directions to form, respectively, a granular compartment and the nucleopod, a specialized uropod occupied by the nucleus and covered with adhesion receptors, including P-selectin glycoprotein ligand-1, CD44, and activated αMβ2 integrin. Ligated IL-5 family receptors localize specifically at the tip of the nucleopod in proximity to downstream signaling partners Janus tyrosine kinase 2, signal transducer and activator of transcription-1 and -5, and extracellular signal-regulated kinase. Microscopy and effects of cytochalasin B and nocodazole indicate that remodeling of filamentous actin and reorientation of the microtubule network are required for eosinophil polarization and nucleopod formation. IL-5 induces persistent polarization and extracellular signal-regulated kinase redistribution that are associated with eosinophil priming, a robust response on subsequent stimulation with N-formyl-methionyl-leucyl-phenylalanine. Global reorganization of cytoskeleton, organelles, adhesion receptors, and signaling molecules likely facilitates vascular arrest, extravasation, migration, granule release, and survival of eosinophils entering inflamed tissues from the bloodstream.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.