ArticleLipids in health and disease2013
Association of COL4A1 genetic polymorphisms with coronary artery disease in Uygur population in Xinjiang, China.
Article in Lipids in health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Basement Membrane-Related Genes C1QTNF3, PTGER2, CAMK2N1, PRSS36, and B3GNT7: Novel Biomarkers for Coronary Artery Disease.Cardiovascular therapeutics · 2026Article
- A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men.Obesity facts · 2022Article
- Detecting methylation quantitative trait loci using a methylation random field method.Briefings in bioinformatics · 2021Article
- Association of COL4A1 (rs605143, rs565470) and CD14 (rs2569190) genes polymorphism with coronary artery disease.Molecular and cellular biochemistry · 2018Article
- TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men.Oncotarget · 2017Article
- Erratum to: The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China.Lipids in health and disease · 2015Article
- Polymorphisms of COL4A1 gene are associated with arterial pulse wave velocity in healthy Han Chinese and Uygur subjects.International journal of clinical and experimental medicine · 2015Article
- Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population.Lipids in health and disease · 2014Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType IV collagen is important for the structural integrity and function of basement membranes. Basement membranes surround vascular smooth muscle cells in the media, COL4A1 is the most abundant component of type IV collagen in all Basement membranes. However, the relationship between COL4A1 genetic polymorphisms and coronary artery disease (CAD) remains unclear. We performed a case-control study to explore the association of COL4A1 genetic polymorphisms with CAD in Uygur population of China.
methods1095 Uygur people (727 men, 368 women) including 471 CAD patients and 624 controls were selected for the present study. Two SNPs (rs605143 and rs565470) were genotyped by using the polymerase chain reaction-restriction fragment length (PCR-RFLP) method.
resultsFor total and men, the rs605143 was found to be associated with CAD by in a dominate model (p = 0.014, p = 0.013, respectively). The difference remained statistically significant after multivariate adjustment (p = 0.036, p = 0.014, respectively). The rs565470 was also found to be associated with CAD in a recessive model for total and men (both p < 0.001), and the difference remained statistically significant after multivariate adjustment (P = 0.002, P = 0.001, respectively).
conclusionBoth rs605143 and rs565470 of COL4A1gene are associated with CAD in Uygur population of China.
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