ArticleBiomedical optics express2013
Axial response of high-resolution microendoscopy in scattering media.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Low-Cost High-Resolution Microendoscopy for the Detection of Esophageal Squamous Cell Neoplasia: An International Trial.Gastroenterology · 2015Trial
- Multiplexed video hyperspectral microendoscopy reveals tumor-immune dynamics in vivo.Research square · 2026Article
- Reduced motion artifacts and speed improvements in enhanced line-scanning fiber bundle endomicroscopy.Journal of biomedical optics · 2021Article
- In vivo imaging of cervical precancer using a low-cost and easy-to-use confocal microendoscope.Biomedical optics express · 2020Article
- Noninvasive diagnostic adjuncts for the evaluation of potentially premalignant oral epithelial lesions: current limitations and future directions.Oral surgery, oral medicine, oral pathology and oral radiology · 2018Review
- Line-scanning confocal microendoscope for nuclear morphometry imaging.Journal of biomedical optics · 2017Article
- Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Line-scanning fiber bundle endomicroscopy with a virtual detector slit.Biomedical optics express · 2016Article
- High speed, line-scanning, fiber bundle fluorescence confocal endomicroscopy for improved mosaicking.Biomedical optics express · 2015Article
- Optimizing modulation frequency for structured illumination in a fiber-optic microendoscope to image nuclear morphometry in columnar epithelium.Biomedical optics express · 2015Article
- Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions.Journal of biomedical optics · 2014Article
- Introduction to the Novel Techniques in Microscopy feature issue.Biomedical optics express · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-resolution microendoscopy (HRME) uses epi-fluorescence imaging with a coherent fiber-optic bundle to enable in vivo examination of cellular morphology. While the HRME platform has recently gained popularity as a simple alternative to confocal endomicroscopy, the axial response of HRME in thick, scattering tissue has yet to be described quantitatively. These details are important because when analyzing images collected by HRME, out-of-focus light may affect the accuracy of quantitative parameters such as nuclear-to-cytoplasm ratio, which has been proposed as a diagnostic indicator of dysplasia or cancer. In this study we investigated the imaging properties of the HRME system by using phantoms simulating scattering tissue with fluorescently labeled nuclei. We directly compared HRME imaging with confocal endomicroscopy in phantoms and in vivo human tissue. HRME images defocused (deep) objects with apparent diameters and intensity levels that are in agreement with a simple geometric model. Out-of-focus nuclei contribute a relatively low, uniform background level to images which neither leads to the erroneous appearance of large nuclei from deep layers, nor prevents accurate imaging of superficial nuclei with high contrast.
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