ArticleBiomedical optics express2013
Imaging the bipolarity of myosin filaments with Interferometric Second Harmonic Generation microscopy.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- All-optical free-space routing of upconverted light by metasurfaces via nonlinear interferometry.Nature nanotechnology · 2024Article
- Second harmonic generation microscopy: a powerful tool for bio-imaging.Biophysical reviews · 2023Review
- Elimination of imaging artifacts in second harmonic generation microscopy using interferometry.Biomedical optics express · 2019Article
- Second harmonic generation polarization microscopy as a tool for protein structure analysis.Biophysics and physicobiology · 2019Article
- Probing microtubules polarity in mitotic spindles in situ using Interferometric Second Harmonic Generation Microscopy.Scientific reports · 2017Article
- Fast interferometric second harmonic generation microscopy.Biomedical optics express · 2016Article
- The Impact of Collagen Fibril Polarity on Second Harmonic Generation Microscopy.Biophysical journal · 2015Article
- Determination of the source of SHG verniers in zebrafish skeletal muscle.Scientific reports · 2015Article
- Myofibrillar misalignment correlated to triad disappearance of mdx mouse gastrocnemius muscle probed by SHG microscopy.Biomedical optics express · 2014Article
- Introduction to the Novel Techniques in Microscopy feature issue.Biomedical optics express · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We report that combining interferometry with Second Harmonic Generation (SHG) microscopy provides valuable information about the relative orientation of noncentrosymmetric structures composing tissues. This is confirmed through the imaging of rat medial gastrocnemius muscle. The inteferometric Second Harmonic Generation (ISHG) images reveal that each side of the myosin filaments composing the A band of the sarcomere generates π phase shifted SHG signal which implies that the myosin proteins at each end of the filaments are oriented in opposite directions. This highlights the bipolar structural organization of the myosin filaments and shows that muscles can be considered as a periodically poled biological structure.
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Registered trials
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