ArticleBiomedical optics express2013
Precise, motion-free polarization control in Second Harmonic Generation microscopy using a liquid crystal modulator in the infinity space.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Assessing collagen alterations in enzymatic degradation models of osteoarthritis via second harmonic generation microscopy.Osteoarthritis and cartilage · 2021Article
- Examining lysyl oxidase-like modulation of collagen architecture in 3D spheroid models of idiopathic pulmonary fibrosis via second-harmonic generation microscopy.Journal of biomedical optics · 2021Article
- Dual-LC PSHG microscopy for imaging collagen type I and type II gels with pixel-resolution analysis.Biomedical optics express · 2021Article
- Recent Advancements in Optical Harmonic Generation Microscopy: Applications and Perspectives.BME frontiers · 2021Review
- Second harmonic generation characterization of collagen in whole bone.Biomedical optics express · 2020Article
- Article
- Probing ECM remodeling in idiopathic pulmonary fibrosis via second harmonic generation microscopy analysis of macro/supramolecular collagen structure.Journal of biomedical optics · 2019Article
- Quantification of collagen fiber structure using second harmonic generation imaging and two-dimensional discrete Fourier transform analysis: Application to the human optic nerve head.Journal of biophotonics · 2019Article
- Characterization of Pancreatic Cancer Tissue Using Multiphoton Excitation Fluorescence and Polarization-Sensitive Harmonic Generation Microscopy.Frontiers in oncology · 2019Article
- Polarization-resolved second harmonic generation imaging of human ovarian cancer.Journal of biomedical optics · 2018Article
- μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure.Scientific reports · 2017Article
- Wavelength-Dependent Second Harmonic Generation Circular Dichroism for Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer Based on Intrinsic Chirality Differences.The journal of physical chemistry. B · 2017Article
- Imaging the Nonlinear Susceptibility Tensor of Collagen by Nonlinear Optical Stokes Ellipsometry.Biophysical journal · 2016Article
- Functional second harmonic generation microscopy probes molecular dynamics with high temporal resolution.Biomedical optics express · 2016Article
- Fast monitoring of in-vivo conformational changes in myosin using single scan polarization-SHG microscopy.Biomedical optics express · 2014Article
- Polarization-modulated second harmonic generation ellipsometric microscopy at video rate.Analytical chemistry · 2014Article
- Introduction: feature issue on optical molecular probes, imaging, and drug delivery.Biomedical optics express · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
Second Harmonic Generation (SHG) microscopy coupled with polarization analysis has great potential for use in tissue characterization, as molecular and supramolecular structural details can be extracted. Such measurements are difficult to perform quickly and accurately. Here we present a new method that uses a liquid crystal modulator (LCM) located in the infinity space of a SHG laser scanning microscope that allows the generation of any desired linear or circular polarization state. As the device contains no moving parts, polarization can be rotated accurately and faster than by manual or motorized control. The performance in terms of polarization purity was validated using Stokes vector polarimetry, and found to have minimal residual polarization ellipticity. SHG polarization imaging characteristics were validated against well-characterized specimens having cylindrical and/or linear symmetries. The LCM has a small footprint and can be implemented easily in any standard microscope and is cost effective relative to other technologies.
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