ArticleBiomedical optics express2013
Evaluation of laser speckle contrast imaging as an intrinsic method to monitor blood brain barrier integrity.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Combining near infrared fluorescence and laser speckle imaging with optical tissue clearing for in vivo transcranial monitoring of cerebral blood vessels damaged by photodynamic nanoformulation.Biomedical optics express · 2024Article
- Visualization of blood-brain barrier disruption with dual-wavelength high-resolution photoacoustic microscopy.Biomedical optics express · 2022Article
- Blood perfusion in Hewes tarsoconjunctival flaps in pigs measured by laser speckle contrast imaging.JPRAS open · 2018Article
- Computational simulation and modeling of the blood-brain barrier pathology.Histochemistry and cell biology · 2018Review
- Continuous multi-modality brain imaging reveals modified neurovascular seizure response after intervention.Biomedical optics express · 2017Article
- A novel effective method for the assessment of microvascular function in male patients with coronary artery disease: a pilot study using laser speckle contrast imaging.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode.Scientific reports · 2015Article
- Flux or speed? Examining speckle contrast imaging of vascular flows.Biomedical optics express · 2015Article
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Authors and funding
6 authors.
Funding
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Abstract
The integrity of the blood brain barrier (BBB) can contribute to the development of many brain disorders. We evaluate laser speckle contrast imaging (LSCI) as an intrinsic modality for monitoring BBB disruptions through simultaneous fluorescence and LSCI with vertical cavity surface emitting lasers (VCSELs). We demonstrated that drug-induced BBB opening was associated with a relative change of the arterial and venous blood velocities. Cross-sectional flow velocity ratio (veins/arteries) decreased significantly in rats treated with BBB-opening drugs, ≤0.81 of initial values.
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