ArticleThe Korean journal of pain2013
The effect of urinary trypsin inhibitor against neuropathic pain in rat models.
Article in The Korean journal of pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Efficacy and Safety Comparison of Ulinastatin Versus Flurbiprofen Axetil for Preemptive Analgesia in Reducing Opioid Burden After Total Knee Arthroplasty: A Randomized Controlled Trial.Journal of pain research · 2025Trial
- Unlocking New Therapeutic Options for Vincristine-Induced Neuropathic Pain: The Impact of Preclinical Research.Life (Basel, Switzerland) · 2024Review
- Ulinastatin inhibits NLRP3-induced apoptosis in a PD cell model.Annals of translational medicine · 2021Article
- Ulinastatin alleviates traumatic brain injury by reducing endothelin-1.Translational neuroscience · 2021Article
- Gabexate mesilate ameliorates the neuropathic pain in a rat model by inhibition of proinflammatory cytokines and nitric oxide pathwayThe Korean journal of pain · 2020Article
- Ulinastatin attenuates neuropathic pain induced by L5-VRT via the calcineurin/IL-10 pathway.Molecular pain · 2016Article
- Autophagy: Can It be a New Experimental Research Method of Neuropathic Pain?The Korean journal of pain · 2015Article
- Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation.The Korean journal of pain · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNerve injury sometimes leads to chronic neuropathic pain associated with neuroinflammation in the nervous system. In the case of chronic neuropathic pain, the inflammatory and algesic mediators become predominant and result in pain hypersensitivity following nervous system damage. It is well known that urinary trypsin inhibitor (ulinastatin, UTI) has an anti-inflammatory activity. Recently, the neuroprotective action of UTI on the nervous system after ischemic injury has been reported. Thus, we evaluated the neuroprotective effect of ulinastatin in a rat model of neuropathic pain.
methodsNeuropathic pain was induced with L5 spinal nerve ligation (SNL) in male Sprague-Dawley rats weighing 100-120 g. The rats were divided into 3 groups, with n = 8 in each group. The rats in the control group (group 1) were administered normal saline and those in group 2 were administered UTI (50,000 U/kg) intravenously through the tail vein for 3 days from the day of SNL. Rats in group 3 were administered UTI (50,000 U/kg) intravenously from the 5(th) day after SNL. The paw withdrawal threshold was measured using the von Frey test for 3 days starting from the 5(th) day after SNL.
resultsThe paw withdrawal thresholds were significantly increased in the rats of group 2 compared to the other groups (P < 0.05).
conclusionsUlinastatin, which was administered for 3 days after SNL, increased the paw withdrawal threshold and it could have a neuroprotective effect in the rat model of neuropathic pain.
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