ArticlePloS one2013
PROX1: a lineage tracer for cortical interneurons originating in the lateral/caudal ganglionic eminence and preoptic area.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 65 citations in OpenAlex.
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- Acquisition and extinction of drug-context memories are linked to distinct epigenetic and transcriptional mechanisms in the mouse dentate gyrus.bioRxiv : the preprint server for biology · 2026Article
- Gene expression mapping of conserved GABAergic interneuron markers in developing zebrafish.Frontiers in molecular neuroscience · 2026Article
- Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety.Cell reports · 2025Article
- Complimentary vertebratebioRxiv : the preprint server for biology · 2025Article
- Genetic approaches to elucidating cortical and hippocampal GABAergic interneuron diversity.Frontiers in cellular neuroscience · 2024Review
- Meso-seq for in-depth transcriptomics in ultra-low amounts of FACS-purified neuronal nuclei.Cell reports methods · 2022Article
- Serotonergic regulation of bipolar cell survival in the developing cerebral cortex.Cell reports · 2022Article
- Development of subdomains in the medial pallium ofFrontiers in neuroanatomy · 2022Article
- Postmitotic Prox1 Expression Controls the Final Specification of Cortical VIP Interneuron Subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior.Cell reports · 2021Article
- Article
- Prox1 inhibits neurite outgrowth during central nervous system development.Cellular and molecular life sciences : CMLS · 2021Article
- Layer-Specific Inhibitory Microcircuits of Layer 6 Interneurons in Rat Prefrontal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- GABAFrontiers in cellular neuroscience · 2021Article
- NADScience advances · 2020Article
- Mining the jewels of the cortex's crowning mystery.Current opinion in neurobiology · 2020Review
- Interneuron Types as Attractors and Controllers.Annual review of neuroscience · 2020Review
- Long-range projections from sparse populations of GABAergic neurons in murine subplate.The Journal of comparative neurology · 2019Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The homeobox-encoding gene Prox1 and its Drosophila homologue prospero are key regulators of cell fate-specification. In the developing rodent cortex a sparse population of cells thought to correspond to late-generated cortical pyramidal neuron precursors expresses PROX1. Using a series of transgenic mice that mark cell lineages in the subcortical telencephalon and, more specifically, different populations of cortical interneurons, we demonstrate that neurons expressing PROX1 do not represent pyramidal neurons or their precursors but are instead subsets of cortical interneurons. These correspond to interneurons originating in the lateral/caudal ganglionic eminence (LGE/CGE) and a small number of preoptic area (POA)-derived neurons. Expression within the cortex can be detected from late embryonic stages onwards when cortical interneurons are still migrating. There is persistent expression in postmitotic cells in the mature brain mainly in the outer cortical layers. PROX1(+ve) interneurons express neurochemical markers such as calretinin, neuropeptide Y, reelin and vasoactive intestinal peptide, all of which are enriched in LGE/CGE- and some POA-derived cells. Unlike in the cortex, in the striatum PROX1 marks nearly all interneurons regardless of their origin. Weak expression of PROX1 can also be detected in oligodendrocyte lineage cells throughout the forebrain. Our data show that PROX1 can be used as a genetic lineage tracer of nearly all LGE/CGE- and subsets POA-derived cortical interneurons at all developmental and postnatal stages in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.