Trial reportPloS one2013
Interaction of central and peripheral factors during repeated sprints at different levels of arterial O2 saturation.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Experiment protocols for brain-body imaging of locomotion: A systematic review.Frontiers in neuroscience · 2023Pooled it
- Exercise modality but not hypoxia alters heart rate variability after a single repeated-sprint session.European journal of applied physiology · 2026Trial
- Acute Effects of Sprint Interval Training and Blood Flow Restriction on Neuromuscular and Muscle Function.Journal of musculoskeletal & neuronal interactions · 2024Trial
- Neuromuscular and perceptual responses during repeated cycling sprints-usefulness of a "hypoxic to normoxic" recovery approach.European journal of applied physiology · 2020Trial
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading.PloS one · 2019Trial
- Acute effects of repeated cycling sprints in hypoxia induced by voluntary hypoventilation.European journal of applied physiology · 2017Trial
- Exercise-related sensations contribute to decrease power during repeated cycle sprints with limited influence on neural drive.European journal of applied physiology · 2017Trial
- Early post-exercise physiological and perceptual responses following different sprint interval training configurations in highly trained national-level swimmers: a randomized crossover study.Frontiers in physiology · 2026Article
- Physiological Responses to Supramaximal Running Exercise with End-Expiratory Breath Holding up to the Breaking Point.Journal of human kinetics · 2024Article
- Impact of systemic hypoxia and blood flow restriction on mechanical, cardiorespiratory, and neuromuscular responses to a multiple-set repeated sprint exercise.Frontiers in physiology · 2024Article
- Hypoventilation training including maximal end-expiratory breath holding improves the ability to repeat high-intensity efforts in elite judo athletes.Frontiers in physiology · 2024Article
- Application of blood flow restriction in hypoxic environment augments muscle deoxygenation without compromising repeated sprint exercise performance.Experimental physiology · 2023Article
- Performance Kinetics During Repeated Sprints is Influenced by Knowledge of Task Endpoint and Associated Peripheral Fatigue.International journal of exercise science · 2023Article
- Maximizing anaerobic performance with repeated-sprint training in hypoxia: In search of an optimal altitude based on pulse oxygen saturation monitoring.Frontiers in physiology · 2022Article
- Hyperoxia Improves Repeated-Sprint Ability and the Associated Training Load in Athletes.Frontiers in sports and active living · 2022Article
- Tent versus Mask-On Acute Effects during Repeated-Sprint Training in Normobaric Hypoxia and Normoxia.Journal of clinical medicine · 2021Article
- Affective and Enjoyment Responses to Sprint Interval Exercise at Different Hypoxia Levels.International journal of environmental research and public health · 2021Article
- Acute performance responses to repeated treadmill sprints in hypoxia with varying inspired oxygen fractions, exercise-to-recovery ratios and recovery modalities.European journal of applied physiology · 2021Article
- Oxygen availability affects exercise capacity, but not neuromuscular fatigue characteristics of knee extensors, during exhaustive intermittent cycling.European journal of applied physiology · 2021Article
- Changes in the quadriceps spinal reflex pathway after repeated sprint cycling are not influenced by ischemic preconditioning.European journal of applied physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the interaction between the development of peripheral locomotor muscle fatigue, muscle recruitment and performance during repeated-sprint exercise (RSE).
methodIn a single-blind, randomised and cross-over design, ten male team-sport athletes performed two RSE (fifteen 5-s cycling sprints interspersed with 25 s of rest; power self-selected) in normoxia and in acute moderate hypoxia (FIO2 0.138). Mechanical work, total electromyographic intensity (summed quadriceps electromyograms, RMSsum) and muscle (vastus lateralis) and pre-fontal cortex near-infrared spectroscopy (NIRS) parameters were calculated for every sprint. Blood lactate concentration ([Lac(-)]) was measured throughout the protocol. Peripheral quadriceps fatigue was assessed via changes in potentiated quadriceps twitch force (ΔQtw,pot) pre- versus post-exercise in response to supra-maximal magnetic femoral nerve stimulation. The central activation ratio (QCAR) was used to quantify completeness of quadriceps activation.
resultsCompared with normoxia, hypoxia reduced arterial oxygen saturation (-13.7%, P=0.001), quadriceps RMSsum (-13.7%, P=0.022), QCAR (-3.3%, P=0.041) and total mechanical work (-8.3%, P=0.019). However, the magnitude of quadriceps fatigue induced by RSE was similar in the two conditions (ΔQtw,pot: -53.5% and -55.1%, P=0.71). The lower cycling performance in hypoxia occurred despite similar metabolic (muscle NIRS parameters and blood [Lac(-)]) and functional (twitch and M-wave) muscle states.
conclusionResults suggest that the central nervous system regulates quadriceps muscle recruitment and, thereby, performance to limit the development of muscle fatigue during intermittent, short sprints. This finding highlights the complex interaction between muscular perturbations and neural adjustments during sprint exercise, and further supports the presence of pacing during intermittent sprint exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.