ArticleFrontiers in plant science2013
Characterization of cell death inducing Phytophthora capsici CRN effectors suggests diverse activities in the host nucleus.
Article in Frontiers in plant science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 64 citations in OpenAlex.
- Identification of Phytophthora cinnamomi CRN effectors and their roles in manipulating cell death during Persea americana infection.BMC genomics · 2024Article
- Deciphering the underlying immune network of the potato defense response inhibition byFrontiers in plant science · 2023Article
- Virulence strategies of an insect herbivore and oomycete plant pathogen converge on host E3 SUMO ligase SIZ1.The New phytologist · 2022Article
- Unraveling Plant Cell Death duringMicroorganisms · 2022Review
- Exploiting Structural Modelling Tools to Explore Host-Translocated Effector Proteins.International journal of molecular sciences · 2021Review
- High-Quality Reference Genome Sequence for the Oomycete Vegetable Pathogen Phytophthora capsici Strain LT1534.Microbiology resource announcements · 2021Article
- Diverse Trajectories Drive the Expression of a Giant Virus in the Oomycete Plant PathogenFrontiers in microbiology · 2021Article
- Effector Repertoire ofFrontiers in genetics · 2020Article
- PpCRN7 and PpCRN20 of Phythophthora parasitica regulate plant cell death leading to enhancement of host susceptibility.BMC plant biology · 2019Article
- The Nuclear-Localized RxLR Effector PvAvh74 FromFrontiers in microbiology · 2019Article
- Arms race: diverse effector proteins with conserved motifs.Plant signaling & behavior · 2019Article
- Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P.Molecular plant pathology · 2018Article
- Random mutagenesis screen shows that Phytophthora capsici CRN83_152-mediated cell death is not required for its virulence function(s).Molecular plant pathology · 2018Article
- Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.BMC biology · 2018Article
- The Multiple Functions of the Nucleolus in Plant Development, Disease and Stress Responses.Frontiers in plant science · 2018Review
- Subcellular Localization Screening ofFrontiers in plant science · 2018Article
- RiCRN1, a Crinkler Effector From the Arbuscular Mycorrhizal FungusFrontiers in microbiology · 2018Article
- Bioinformatic characterisation of the effector repertoire of the strawberry pathogen Phytophthora cactorum.PloS one · 2018Article
- Quantitative analysis of the tomato nuclear proteome during Phytophthora capsici infection unveils regulators of immunity.The New phytologist · 2017Article
- A novel Meloidogyne enterolobii effector MeTCTP promotes parasitism by suppressing programmed cell death in host plants.Molecular plant pathology · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
Plant-Microbe interactions are complex associations that feature recognition of Pathogen Associated Molecular Patterns by the plant immune system and dampening of subsequent responses by pathogen encoded secreted effectors. With large effector repertoires now identified in a range of sequenced microbial genomes, much attention centers on understanding their roles in immunity or disease. These studies not only allow identification of pathogen virulence factors and strategies, they also provide an important molecular toolset suited for studying immunity in plants. The Phytophthora intracellular effector repertoire encodes a large class of proteins that translocate into host cells and exclusively target the host nucleus. Recent functional studies have implicated the CRN protein family as an important class of diverse effectors that target distinct subnuclear compartments and modify host cell signaling. Here, we characterized three necrosis inducing CRNs and show that there are differences in the levels of cell death. We show that only expression of CRN20_624 has an additive effect on PAMP induced cell death but not AVR3a induced ETI. Given their distinctive phenotypes, we assessed localization of each CRN with a set of nuclear markers and found clear differences in CRN subnuclear distribution patterns. These assays also revealed that expression of CRN83_152 leads to a distinct change in nuclear chromatin organization, suggesting a distinct series of events that leads to cell death upon over-expression. Taken together, our results suggest diverse functions carried by CRN C-termini, which can be exploited to identify novel processes that take place in the host nucleus and are required for immunity or susceptibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.