ArticleFrontiers in psychiatry2013
Association of the Nicotinic Receptor α7 Subunit Gene (CHRNA7) with Schizophrenia and Visual Backward Masking.
Article in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 39 citations in OpenAlex.
- Intact Serial Dependence in Schizophrenia: Evidence from an Orientation Adjustment Task.Schizophrenia bulletin · 2025Article
- Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype.Translational psychiatry · 2022Article
- Schizophrenia Hypothesis: Autonomic Nervous System Dysregulation of Fetal and Adult Immune Tolerance.Frontiers in systems neuroscience · 2022Article
- Neural Compensation Mechanisms of Siblings of Schizophrenia Patients as Revealed by High-Density EEG.Schizophrenia bulletin · 2020Article
- Examining motion speed processing in schizophrenia using the flash lag illusion.Schizophrenia research. Cognition · 2020Article
- Associations between genetic variations and global motion perception.Experimental brain research · 2019Article
- CHRFAM7A alters binding to the neuronal alpha-7 nicotinic acetylcholine receptor.Neuroscience letters · 2019Article
- Sex-related differences in vision are heterogeneous.Scientific reports · 2018Article
- Tobacco Use Decreases Visual Sensitivity in Schizophrenia.Frontiers in psychology · 2018Article
- Evolution in Neuromodulation-The Differential Roles of Acetylcholine in Higher Order Association vs. Primary Visual Cortices.Frontiers in neural circuits · 2018Review
- Kynurenine pathway and cognitive impairments in schizophrenia: Pharmacogenetics of galantamine and memantine.Schizophrenia research. Cognition · 2016Article
- Ageing and visual spatiotemporal processing.Experimental brain research · 2015Article
- Does chronic nicotine consumption influence visual backward masking in schizophrenia and schizotypy?Schizophrenia research. Cognition · 2015Article
- Visual masking & schizophrenia.Schizophrenia research. Cognition · 2015Review
- CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Small effects of smoking on visual spatiotemporal processing.Scientific reports · 2014Article
- Targeting brain α7 nicotinic acetylcholine receptors in Alzheimer's disease: rationale and current status.CNS drugs · 2014Review
- Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia.Biomedical reports · 2014Article
- Genetics and smoking.Current addiction reports · 2014Article
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention. Here, we investigated five single nucleotide polymorphisms (SNPs) [rs3826029] [rs2337506] [rs982574] [rs904952] [rs2337980] of the cholinergic nicotinic receptor gene, alpha 7 subunit (CHRNA7) and their association to schizophrenia. We found an association with rs904952 (p = 0.009) in a German sample of 224 schizophrenic patients and 224 healthy control subjects. The same trend was shown in an independent Georgian sample of 50 schizophrenic patients, 57 first order unaffected relatives, and 51 healthy controls. In addition, visual backward masking (VBM), a sensitive test for early visual information processing, was assessed in the Georgian sample. In line with prior studies, VBM performance deficits were much more pronounced in schizophrenic patients and their unaffected relatives compared to healthy controls (schizophrenic patients: 156 ms; unaffected relatives: 60 ms; healthy controls: 33 ms). VBM was strongly correlated with SNP rs904952 (H[2] = 7.3, p = 0.026). Our results further support the notion that changes in the nicotinic system are involved in schizophrenia and open the avenue for pharmacological intervention.
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