ArticleFrontiers in neural circuits2013
Activation of high and low affinity dopamine receptors generates a closed loop that maintains a conductance ratio and its activity correlate.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Feeding state-specific hormonal tuning of neural circuit modulation.Journal of neurophysiology · 2025Article
- Peptidergic Modulation of the Lobster Cardiac System Has Opposing Action on Neurons and Muscles.Integrative organismal biology (Oxford, England) · 2025Article
- Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Graded Transmission without Action Potentials Sustains Rhythmic Activity in Some But Not All Modulators That Activate the Same Current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Removal of endogenous neuromodulators in a small motor network enhances responsiveness to neuromodulation.Journal of neurophysiology · 2017Article
- Homeostatic plasticity of excitability in crustacean central pattern generator networks.Current opinion in neurobiology · 2017Review
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
- Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms.Current opinion in neurobiology · 2015Review
- Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.Frontiers in neural circuits · 2015Article
- Article
- Channeling the Central Dogma.Neuron · 2014Article
- Dopaminergic tone persistently regulates voltage-gated ion current densities through the D1R-PKA axis, RNA polymerase II transcription, RNAi, mTORC1, and translation.Frontiers in cellular neuroscience · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Neuromodulators alter network output and have the potential to destabilize a circuit. The mechanisms maintaining stability in the face of neuromodulation are not well described. Using the pyloric network in the crustacean stomatogastric nervous system, we show that dopamine (DA) does not simply alter circuit output, but activates a closed loop in which DA-induced alterations in circuit output consequently drive a change in an ionic conductance to preserve a conductance ratio and its activity correlate. DA acted at low affinity type 1 receptors (D1Rs) to induce an immediate modulatory decrease in the transient potassium current (IA) of a pyloric neuron. This, in turn, advanced the activity phase of that component neuron, which disrupted its network function and thereby destabilized the circuit. DA simultaneously acted at high affinity D1Rs on the same neuron to confer activity-dependence upon the hyperpolarization activated current (Ih) such that the DA-induced changes in activity subsequently reduced Ih. This DA-enabled, activity-dependent, intrinsic plasticity exactly compensated for the modulatory decrease in IA to restore the IA:Ih ratio and neuronal activity phase, thereby closing an open loop created by the modulator. Activation of closed loops to preserve conductance ratios may represent a fundamental operating principle neuromodulatory systems use to ensure stability in their target networks.
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