ArticleFrontiers in neural circuits2013
Optogenetic stimulation effectively enhances intrinsically generated network synchrony.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis.Scientific reports · 2020Article
- Low-Temperature Atomic Layer Deposited Oxide on Titanium Nitride Electrodes Enables Culture and Physiological Recording of Electrogenic Cells.Frontiers in neuroscience · 2020Article
- Loss of MeCP2 in immature neurons leads to impaired network integration.Human molecular genetics · 2019Article
- Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2017Article
- Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks.Scientific reports · 2016Article
- Optogenetic tools for modulating and probing the epileptic network.Epilepsy research · 2015Review
- Revealing neuronal function through microelectrode array recordings.Frontiers in neuroscience · 2014Review
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Authors and funding
7 authors.
Funding
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Abstract
Synchronized bursting is found in many brain areas and has also been implicated in the pathophysiology of neuropsychiatric disorders such as epilepsy, Parkinson's disease, and schizophrenia. Despite extensive studies of network burst synchronization, it is insufficiently understood how this type of network wide synchronization can be strengthened, reduced, or even abolished. We combined electrical recording using multi-electrode array with optical stimulation of cultured channelrhodopsin-2 transducted hippocampal neurons to study and manipulate network burst synchronization. We found low frequency photo-stimulation protocols that are sufficient to induce potentiation of network bursting, modifying bursting dynamics, and increasing interneuronal synchronization. Surprisingly, slowly fading-in light stimulation, which substantially delayed and reduced light-driven spiking, was at least as effective in reorganizing network dynamics as much stronger pulsed light stimulation. Our study shows that mild stimulation protocols that do not enforce particular activity patterns onto the network can be highly effective inducers of network-level plasticity.
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Registered trials
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