ArticleCancer research and treatment2013
Impact of Chemoradiation on Prognosis in Stage IVB Cervical Cancer with Distant Lymphatic Metastasis.
Article in Cancer research and treatment, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Efficacy and Safety of Concurrent Chemoradiotherapy as First-Line Treatment for Stage IVB Cervical Cancer: A Single-Center Retrospective Observational Study.The journal of obstetrics and gynaecology research · 2025Observational
- Management of Stage IVB Cervical Cancer Including the Role of Radiotherapy.Current treatment options in oncology · 2025Review
- Article
- Intensity-Modulated Radiation Therapy for Uterine Cervical Cancer to Reduce Toxicity and Enhance Efficacy - an Option or a Must?: A Narrative Review.Cancer research and treatment · 2024Review
- Outcomes associated with treatment to all sites of disease in patients with stage IVB cancer of the cervix.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Article
- Definitive vs palliative pelvic radiation for patients with newly diagnosed stage IVB cervical cancer treated with bevacizumab - An exploratory study.Gynecologic oncology reports · 2022Article
- Dynamic Nomogram Based on the Metastatic Number and Sites and Therapy Strategies Predicting the Prognosis of Patients with Metastatic Cervical Cancer.International journal of women's health · 2022Article
- Survival, treatment pattern, and treatment outcome in patients with cervical cancer metastatic to distant lymph nodes.Frontiers in oncology · 2022Article
- Defining the role of high-dose radiation in oligometastatic & oligorecurrent cervical cancer.The Indian journal of medical research · 2021Review
- Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer.Current oncology (Toronto, Ont.) · 2021Article
- A Nomogram-Based Risk Classification System Predicting the Overall Survival of Patients With Newly Diagnosed Stage IVB Cervix Uteri Carcinoma.Frontiers in medicine · 2021Article
- Surgery of primary sites for stage IVB cervical cancer patients receiving chemoradiotherapy: a population-based study.Journal of gynecologic oncology · 2020Article
- Clinicopathologic characteristics and survival analysis in stage IVB cervical cancer with hematogenous metastasis.Translational cancer research · 2019Article
- Detection of distant metastatic disease by positron emission tomography withInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2019Article
- Score for the Overall Survival Probability of Patients With First-Diagnosed Distantly Metastatic Cervical Cancer: A Novel Nomogram-Based Risk Assessment System.Frontiers in oncology · 2019Article
- Race and nodal disease status are prognostic factors in patients with stage IVB cervical cancer.Oncotarget · 2018Article
- Selection and identification of novel peptides specifically targeting human cervical cancer.Amino acids · 2018Article
- Advances in diagnosis and treatment of metastatic cervical cancer.Journal of gynecologic oncology · 2016Review
- HER2 as a novel therapeutic target for cervical cancer.Oncotarget · 2015Article
- Tailored radiotherapeutic strategies for disseminated uterine cervical cancer patients.Radiation oncology (London, England) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to determine whether chemoradiation (CCR) is efficient for improving prognosis, compared with systemic chemotherapy (SC), in patients with stage IVB cervical cancer who have distant lymphatic metastasis. MATERIALS AND
methodsAmong 2,322 patients with cervical cancer between January 2000 and March 2010, 43 patients (1.9%) had stage IVB disease. After exclusion of 19 patients due to insufficient data and hematogenous metastasis, 24 patients (1%) who received CCR (n=10) or SC (n=14) were enrolled. We compared tumor response, progression-free survival (PFS) and overall survival (OS), and disease recurrence between CCR and SC.
resultsComplete response rates were 60% and 0% after CCR and SC (p<0.01). Grade 3 or 4 leukopenia was more common in patients treated with CCR (24.4% vs. 9.1%, p=0.03), whereas grade 3 or 4 neuropenia was more frequent in those treated with SC (28.4% vs. 11.1%, p=0.03). Development of grade 3 proctitis occurred as a late radiotherapy (RT)-related toxicity in only one patient (10%) treated with CCR. In addition, squamous cell carcinoma and CCR were favorable prognostic factors for improvement of PFS (adjusted hazard ratios [HRs], 0.17 and 0.12; 95% confidence intervals [CIs], 0.04 to 0.80 and 0.03 to 0.61), and only CCR was significant for improvement of OS (adjusted HR, 0.15; 95% CI, 0.02 to 0.90). However, no differences in the rate and pattern of disease recurrence were observed between CCR and SC.
conclusionCCR may be more effective than SC for improving survival, and can be regarded as a feasible method with some caution regarding late RT-related toxicity for treatment of stage IVB cervical cancer with distant lymphatic metastasis.
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