ArticleJournal of virology2014
Echovirus 7 entry into polarized caco-2 intestinal epithelial cells involves core components of the autophagy machinery.
Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- mCellular and molecular life sciences : CMLS · 2025Article
- Echovirus induces autophagy to promote viral replicationFrontiers in immunology · 2023Article
- Autophagy and white spot syndrome virus infection in crustaceans.Fish and shellfish immunology reports · 2022Review
- Molecular Pathogenicity of Enteroviruses Causing Neurological Disease.Frontiers in microbiology · 2020Review
- The Intertwined Life Cycles of Enterovirus and Autophagy.Virulence · 2019Review
- Endophilin-A2-mediated endocytic pathway is critical for enterovirus 71 entry into caco-2 cells.Emerging microbes & infections · 2019Article
- Autophagy-Associated Proteins Control Ebola Virus Internalization Into Host Cells.The Journal of infectious diseases · 2018Article
- Non-canonical Functions of Macroautophagy Proteins During Endocytosis by Myeloid Antigen Presenting Cells.Frontiers in immunology · 2018Review
- Early activation of MyD88-mediated autophagy sustains HSV-1 replication in human monocytic THP-1 cells.Scientific reports · 2016Article
- The Autophagic Machinery in Enterovirus Infection.Viruses · 2016Review
- ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.PLoS pathogens · 2015Article
- Autophagy, viruses, and intestinal immunity.Current opinion in gastroenterology · 2014Review
- Genome-wide small interfering RNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration.Journal of virology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Echovirus 7 enters polarized Caco-2 intestinal epithelial cells by a clathrin-mediated endocytic process and then moves through the endosomal system before releasing its genome into the cytoplasm. We examined the possible role in virus entry of core components of the autophagy machinery. We found that depletion of Beclin-1, Atg12, Atg14, Atg16, or LC3 with specific small interfering RNAs inhibited echovirus 7 infection upstream of uncoating but had little or no effect on virus attachment to the cell surface. These data indicate that multiple autophagy-related proteins are important for one or more events that occur after the virus has bound its receptor on the cell surface but before RNA is released from the virus capsid. Although we have not determined the mechanism by which each protein contributes to virus entry, we found that stable depletion of Atg16L1 interfered with virus internalization from the cell surface rather than with intracellular trafficking. Autophagy gene products may thus participate in the endocytic process that moves virus into polarized Caco-2 cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.