ArticleThe Journal of cell biology1985
Cross-bridges mediate anterograde and retrograde vesicle transport along microtubules in squid axoplasm.
Article in The Journal of cell biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 191 citations in OpenAlex.
- Nanometer-resolution tracking of single cargo reveals dynein motor mechanisms.Nature chemical biology · 2025Article
- Tuning ensemble-averaged cargo run length via fractional change in mean kinesin number.Physical biology · 2021Article
- Different motilities of microtubules driven by kinesin-1 and kinesin-14 motors patterned on nanopillars.Science advances · 2020Article
- Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury.Cell death & disease · 2017Article
- Reactive oxygen species induce neurite degeneration before induction of cell death.Journal of clinical biochemistry and nutrition · 2016Article
- Microtubule Defects Influence Kinesin-Based Transport In Vitro.Biophysical journal · 2016Article
- Kinesin, 30 years later: Recent insights from structural studies.Protein science : a publication of the Protein Society · 2015Review
- Cooperative protofilament switching emerges from inter-motor interference in multiple-motor transport.Scientific reports · 2014Article
- A method for multiprotein assembly in cells reveals independent action of kinesins in complex.The Journal of cell biology · 2014Article
- CK2 activates kinesin via induction of a conformational change.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels.Journal of cell science · 2013Article
- Tuning multiple motor travel via single motor velocity.Traffic (Copenhagen, Denmark) · 2012Article
- Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport.Current biology : CB · 2010Article
- Transport of beads by several kinesin motors.Biophysical journal · 2008Article
- The distance that kinesin-1 holds its cargo from the microtubule surface measured by fluorescence interference contrast microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Calsyntenin-1 docks vesicular cargo to kinesin-1.Molecular biology of the cell · 2006Article
- Cooperative cargo transport by several molecular motors.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Direct inhibition of microtubule-based kinesin motility by local anesthetics.Biophysical journal · 2000Article
- Migration of mitochondria to viral assembly sites in African swine fever virus-infected cells.Journal of virology · 1998Article
- Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin.Biophysical journal · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assay the detailed structural relationship between axonally transported vesicles and their substrate microtubules, vesicle transport was focally cold blocked in axoplasm that was extruded from the squid giant axon. A brief localized cold block concentrated anterogradely and retrogradely transported vesicles selectively on either the proximal or or distal side of the block. Normal movement of the concentrated vesicles was reactivated by rewarming the cold-blocked axoplasm. At the periphery of the axoplasm, moving vesicles were located on individual microtubules that had become separated from the other cytomatrix components. The presence of moving vesicles on isolated microtubules permitted the identification of the structural components required for vesicle transport along microtubules. The results show that 16-18-nm cross-bridges connect both anterogradely and retrogradely moving vesicles to their substrate microtubules. These observations demonstrate that cross-bridges are fundamental are fundamental components of vesicle transport along axonal microtubules. Thus, vesicle transport can now be included among those cell motile systems such as muscle and axonemes that are based on a cross-bridge-mediated mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.